Didmolamide A and B, Two New Cyclic Hexapeptides from the Marine Ascidian Didemnum molle
Two novel cyclic hexapeptides, didmolamides A and B, were isolated from the compound ascidian Didemnum molle collected in Madagascar. The structure of the two peptides was elucidated by interpretation of MS, COSY, HMQC, and HMBC data. The absolute configuration of all amino acids was determined to b...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2003-04, Vol.66 (4), p.575-577 |
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| container_title | Journal of natural products (Washington, D.C.) |
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| creator | RUDI, Amira CHILL, Liat AKNIN, Maurice KASHMAN, Yoel |
| description | Two novel cyclic hexapeptides, didmolamides A and B, were isolated from the compound ascidian Didemnum molle collected in Madagascar. The structure of the two peptides was elucidated by interpretation of MS, COSY, HMQC, and HMBC data. The absolute configuration of all amino acids was determined to be l using Marfey's method for HPLC. |
| doi_str_mv | 10.1021/np020531w |
| format | Article |
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| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 2003-04, Vol.66 (4), p.575-577 |
| issn | 0163-3864 1520-6025 |
| language | eng |
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| source | MEDLINE; ACS Publications |
| subjects | Amino Acids - chemistry Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Chromatography, High Pressure Liquid Didemnum molle Didmolamide A Didmolamide B Drug Screening Assays, Antitumor Fundamental and applied biological sciences. Psychology Humans Inhibitory Concentration 50 Madagascar Marine Mass Spectrometry Molecular Structure natural products Peptides, Cyclic - chemistry Peptides, Cyclic - isolation & purification Peptides, Cyclic - pharmacology Proteins Tumor Cells, Cultured - drug effects Urochordata - chemistry |
| title | Didmolamide A and B, Two New Cyclic Hexapeptides from the Marine Ascidian Didemnum molle |
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