TNF-α Antagonist and Vascular Inflammation in Patients with Psoriasis Vulgaris: A Randomized Placebo-Controlled Study

Vascular inflammation is increased in patients with psoriasis. This randomized, double-blind, multicenter study evaluated the effects of tumor necrosis factor-α antagonist adalimumab on vascular inflammation in patients with psoriasis. A total of 107 patients were randomized (1:1) to receive adalimu...

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Veröffentlicht in:	Journal of investigative dermatology 2017-08, Vol.137 (8), p.1638-1645
Hauptverfasser:	Bissonnette, Robert, Harel, François, Krueger, James G., Guertin, Marie-Claude, Chabot-Blanchet, Malorie, Gonzalez, Juana, Maari, Catherine, Delorme, Isabelle, Lynde, Charles W., Tardif, Jean-Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	Adalimumab - administration & dosage Anti-Inflammatory Agents - administration & dosage Aorta, Thoracic - drug effects Aorta, Thoracic - metabolism Aorta, Thoracic - pathology Dose-Response Relationship, Drug Double-Blind Method Female Follow-Up Studies Humans Inflammation - drug therapy Inflammation - metabolism Inflammation - pathology Male Middle Aged Psoriasis - drug therapy Psoriasis - metabolism Psoriasis - pathology Time Factors Treatment Outcome Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism
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