Mitochondrial Function and Cell Size: An Allometric Relationship
Allometric scaling of metabolic rate results in lower total mitochondrial oxygen consumption with increasing organismal size. This is considered a universal law in biology. Here, we discuss how allometric laws impose size-dependent limits to mitochondrial activity at the cellular level. This cell-si...
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| Veröffentlicht in: | Trends in cell biology 2017-06, Vol.27 (6), p.393-402 |
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| creator | Miettinen, Teemu P Björklund, Mikael |
| description | Allometric scaling of metabolic rate results in lower total mitochondrial oxygen consumption with increasing organismal size. This is considered a universal law in biology. Here, we discuss how allometric laws impose size-dependent limits to mitochondrial activity at the cellular level. This cell-size-dependent mitochondrial metabolic activity results in nonlinear scaling of metabolism in proliferating cells, which can explain size homeostasis. The allometry in mitochondrial activity can be controlled through mitochondrial fusion and fission machinery, suggesting that mitochondrial connectivity can bypass transport limitations, the presumed biophysical basis for allometry. As physical size affects cellular functionality, cell-size-dependent metabolism becomes directly relevant for development, metabolic diseases, and aging. |
| doi_str_mv | 10.1016/j.tcb.2017.02.006 |
| format | Article |
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| ispartof | Trends in cell biology, 2017-06, Vol.27 (6), p.393-402 |
| issn | 0962-8924 1879-3088 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aging Allometry Animals Cell Division Cell Size Cells Homeostasis Machinery and equipment Maximum oxygen consumption Metabolic disorders Metabolic rate Metabolism Mitochondria Mitochondria - metabolism Mitochondrial Dynamics Models, Biological Oxygen consumption Pathology Scaling Size Studies |
| title | Mitochondrial Function and Cell Size: An Allometric Relationship |
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