Functional analysis of carboxylesterase in human induced pluripotent stem cell-derived enterocytes

Human carboxylesterase (CES) is a key esterase involved in the metabolism and biotransformation of drugs. Hydrolysis activity in the human small intestine is predominantly mediated by CES2A1 rather than CES1A. In drug development studies, Caco-2 cells are commonly used as a model to predict drug abs...

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Veröffentlicht in:	Biochemical and biophysical research communications 2017-04, Vol.486 (1), p.143-148
Hauptverfasser:	Kabeya, Tomoki, Matsumura, Wakana, Iwao, Takahiro, Hosokawa, Masakiyo, Matsunaga, Tamihide
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzimidazoles - pharmacology Benzoates - pharmacology Blotting, Western Caco-2 Cells Caco-2 cells Carboxylesterase Carboxylesterase - antagonists & inhibitors Carboxylesterase - genetics Carboxylesterase - metabolism Cell Differentiation Cell Line Enterocytes Enterocytes - cytology Enterocytes - enzymology Enterocytes - metabolism Gene Expression Human induced pluripotent stem cells Humans Hydrolysis - drug effects Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - enzymology Induced Pluripotent Stem Cells - metabolism Intestine, Small - enzymology Intestine, Small - metabolism Isoenzymes - antagonists & inhibitors Isoenzymes - genetics Isoenzymes - metabolism Metabolic activity Nitrophenols - metabolism Reverse Transcriptase Polymerase Chain Reaction Substrate Specificity
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