Total synthesis and antileukemic evaluations of the phenazine 5,10-dioxide natural products iodinin, myxin and their derivatives

[Display omitted] A new efficient total synthesis of the phenazine 5,10-dioxide natural products iodinin and myxin and new compounds derived from them was achieved in few steps, a key-step being 1,6-dihydroxyphenazine di-N-oxidation. Analogues prepared from iodinin, including myxin and 2-ethoxy-2-ox...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2017-04, Vol.25 (7), p.2285-2293
Hauptverfasser:	Viktorsson, Elvar Örn, Melling Grøthe, Bendik, Aesoy, Reidun, Sabir, Misbah, Snellingen, Simen, Prandina, Anthony, Høgmoen Åstrand, Ove Alexander, Bonge-Hansen, Tore, Døskeland, Stein Ove, Herfindal, Lars, Rongved, Pål
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Biological Products - chemical synthesis Biological Products - pharmacology Cell Line, Tumor Humans Hypoxia selectivity Phenazine 5,10-dioxides Phenazines Phenazines - chemical synthesis Phenazines - chemistry Phenazines - pharmacology Structure-Activity Relationship
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