Synthesis of novel 1,2,4-triazine scaffold as FAK inhibitors with antitumor activity

[Display omitted] A series of 1,3,5-triazinic inhibitors of focal adhesion kinase (FAK) has recently been shown to exert antiangiogenic activity against HUVEC cells and anticancer efficacy against several cancer cell lines. In this report, we designed and synthesized a series of new compounds contai...

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