Efficient production of trophoblast lineage cells from human induced pluripotent stem cells

Human induced pluripotent stem cells (hiPSCs) are potentially useful in both clinical applications and basic biological research. hiPSCs can differentiate into extra-embryonic cells in the presence of BMP4. However, the differentiation potential of hiPSCs can be affected by culture conditions or gen...

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Veröffentlicht in:	Laboratory investigation 2017-10, Vol.97 (10), p.1188-1200
Hauptverfasser:	Kojima, Junya, Fukuda, Atsushi, Taira, Hayato, Kawasaki, Tomoyuki, Ito, Hiroe, Kuji, Naoaki, Isaka, Keiichi, Umezawa, Akihiro, Akutsu, Hidenori
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 14/34 631/443/494 631/532/1360 631/532/2064/2158 Animals Biological research Biomarkers Bone Morphogenetic Protein 4 - metabolism Cell culture Cell Differentiation - physiology Cell Survival - physiology Cells, Cultured Chromatin Differentiation Female Fibroblast growth factor 2 Gene expression Gene Expression Profiling Genes Genetic diversity Genetic Markers - genetics Histocompatibility antigen HLA Humans Induced Pluripotent Stem Cells - metabolism Keratin-7 - metabolism Laboratory Medicine Medicine Medicine & Public Health Mice Microscopy, Fluorescence miRNA Pathology Pluripotency research-article Ribonucleic acid RNA Stem cells Therapeutic applications Trophoblasts - metabolism
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