Plectin deficiency in liver cancer cells promotes cell migration and sensitivity to sorafenib treatment

Plectin involved in activation of kinases in cell signaling pathway and plays important role in cell morphology and migration. Plectin knockdown promotes cell migration by activating focal adhesion kinase and Rac1-GTPase activity in liver cells. Sorafenib is a multi-targeting tyrosine kinase inhibit...

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Veröffentlicht in:	Cell adhesion & migration 2018-01, Vol.12 (1), p.19-27
Hauptverfasser:	Cheng, Chiung-Chi, Chao, Wei-Ting, Liao, Chen-Chun, Tseng, Yu-Hui, Lai, Yen-Chang Clark, Lai, Yih-Shyong, Hsu, Yung-Hsiang, Liu, Yi-Hsiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - therapeutic use Apoptosis - drug effects Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Cell Survival - drug effects collective cell migration cytoskeleton E-cadherin Hep G2 Cells hepatocellular carcinoma Humans Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - pathology plectin Plectin - deficiency Protein Kinase Inhibitors - pharmacology Research Paper Signal Transduction - drug effects sorafenib Sorafenib - pharmacology
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