miR-146a mediates inflammatory changes and fibrosis in the heart in diabetes

Abstract Hyperglycemia induced endothelial injury is a key pathogenetic factor in diabetic cardiomyopathy. In diabetes, changes in pro-inflammatory cytokines are a key mechanism leading to cardiac fibrosis. We have previously demonstrated alteration of miR-146a in chronic diabetic complications. Her...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2017-04, Vol.105, p.70-76
Hauptverfasser:	Feng, Biao, Chen, Shali, Gordon, Andrew Devon, Chakrabarti, Subrata
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiovascular Cytokines - genetics Cytokines - metabolism Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Diabetic cardiomyopathy Echocardiography Endothelial Cells - metabolism Fibrosis Gene Expression Regulation Inflammation Mediators - metabolism Inflammatory Interleukin-1 Receptor-Associated Kinases - metabolism Mice MicroRNAs - genetics Myocarditis - etiology Myocarditis - metabolism Myocarditis - pathology Myocardium - metabolism Myocardium - pathology NF-kappa B - metabolism NF-κB Signal Transduction TNF Receptor-Associated Factor 6 - metabolism
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