Regulation of Embryonic Stem Cell Self-Renewal and Differentiation by MicroRNAs
MicroRNAs (miRNAs) are posttranscriptional regulators of gene expression. They play an important role in various cellular processes such as apoptosis, differentiation, secretion, and proliferation. Embryonic stem cells (ESCs) are derived from the inner cell mass of the blastocyst stage of the embryo...
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| Veröffentlicht in: | Cellular reprogramming 2017-06, Vol.19 (3), p.150-158 |
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| container_title | Cellular reprogramming |
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| creator | Ran, Xi Xiao, Chun-Hong Xiang, Gui-Ming Ran, Xin-Ze |
| description | MicroRNAs (miRNAs) are posttranscriptional regulators of gene expression. They play an important role in various cellular processes such as apoptosis, differentiation, secretion, and proliferation. Embryonic stem cells (ESCs) are derived from the inner cell mass of the blastocyst stage of the embryo. miRNAs are critical factors for the self-renewal and differentiation of ESCs. In this review, we will focus on the role of miRNAs in the self-renewal and directional differentiation of ESCs. We will present the current knowledge on key points related to miRNA biogenesis and their function in ESCs. |
| doi_str_mv | 10.1089/cell.2016.0048 |
| format | Article |
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We will present the current knowledge on key points related to miRNA biogenesis and their function in ESCs.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Cell Differentiation - physiology</subject><subject>Cell proliferation</subject><subject>Cell self-renewal</subject><subject>Differentiation</subject><subject>Embryo cells</subject><subject>Embryos</subject><subject>Gene expression</subject><subject>Human Embryonic Stem Cells - cytology</subject><subject>Human Embryonic Stem Cells - metabolism</subject><subject>Humans</subject><subject>MicroRNAs</subject><subject>MicroRNAs - metabolism</subject><subject>miRNA</subject><subject>Post-transcription</subject><subject>Regulators</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Secretion</subject><subject>Stem cells</subject><issn>2152-4971</issn><issn>2152-4998</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkDtPwzAURi0EolXpyogssbAk2NeJH2NVykMqVGphtuLURqnyKHEi1H-PoxYGvFwP5_uufRC6piSmRKr73JZlDITymJBEnqEx0BSiRCl5_ncXdISm3u9IOIyFGL9EI5AghEhhjFZr-9mXWVc0NW4cXlSmPTR1keNNZys8DwvwxpYuWtvafmclzuotfiics62tu-KYMwf8WuRts36b-St04bLS2-lpTtDH4-J9_hwtV08v89kyyhmwLtryxPGcGCNy43hqJZVAM1CUAHFSJMpSyYFzBhkVlIIzBoxTTIkcZAizCbo79u7b5qu3vtNV4QcfWW2b3msqBU8UCAIBvf2H7pq-rcPrNFWQpAyCiUDFRyp8xPvWOr1viyprD5oSPdjWQ7sebOvBdgjcnGp7U9ntH_7rlv0ASVV4bQ</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Ran, Xi</creator><creator>Xiao, Chun-Hong</creator><creator>Xiang, Gui-Ming</creator><creator>Ran, Xin-Ze</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201706</creationdate><title>Regulation of Embryonic Stem Cell Self-Renewal and Differentiation by MicroRNAs</title><author>Ran, Xi ; Xiao, Chun-Hong ; Xiang, Gui-Ming ; Ran, Xin-Ze</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c323t-d64f6c0bb7cbf65e81821a291020f8749e18626632a17112fbb2bf9397c28d643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Cell Differentiation - physiology</topic><topic>Cell proliferation</topic><topic>Cell self-renewal</topic><topic>Differentiation</topic><topic>Embryo cells</topic><topic>Embryos</topic><topic>Gene expression</topic><topic>Human Embryonic Stem Cells - cytology</topic><topic>Human Embryonic Stem Cells - metabolism</topic><topic>Humans</topic><topic>MicroRNAs</topic><topic>MicroRNAs - metabolism</topic><topic>miRNA</topic><topic>Post-transcription</topic><topic>Regulators</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Secretion</topic><topic>Stem cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ran, Xi</creatorcontrib><creatorcontrib>Xiao, Chun-Hong</creatorcontrib><creatorcontrib>Xiang, Gui-Ming</creatorcontrib><creatorcontrib>Ran, Xin-Ze</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cellular reprogramming</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ran, Xi</au><au>Xiao, Chun-Hong</au><au>Xiang, Gui-Ming</au><au>Ran, Xin-Ze</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of Embryonic Stem Cell Self-Renewal and Differentiation by MicroRNAs</atitle><jtitle>Cellular reprogramming</jtitle><addtitle>Cell Reprogram</addtitle><date>2017-06</date><risdate>2017</risdate><volume>19</volume><issue>3</issue><spage>150</spage><epage>158</epage><pages>150-158</pages><issn>2152-4971</issn><eissn>2152-4998</eissn><abstract>MicroRNAs (miRNAs) are posttranscriptional regulators of gene expression. 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| ispartof | Cellular reprogramming, 2017-06, Vol.19 (3), p.150-158 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Apoptosis Cell Differentiation - physiology Cell proliferation Cell self-renewal Differentiation Embryo cells Embryos Gene expression Human Embryonic Stem Cells - cytology Human Embryonic Stem Cells - metabolism Humans MicroRNAs MicroRNAs - metabolism miRNA Post-transcription Regulators Ribonucleic acid RNA Secretion Stem cells |
| title | Regulation of Embryonic Stem Cell Self-Renewal and Differentiation by MicroRNAs |
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