Calcium-sensing receptor-mediated mitogen-activated protein kinase pathway improves the status of transplanted mouse embryonic stem cells in rats with acute myocardial infarction

Several studies have identified the critical role of calcium-sensing receptors (CaSRs) in cardiac ischaemia/reperfusion injury and cardiac hypertrophy and have demonstrated that CaSRs induce myocardial apoptosis by activating MAPKs. Using acute myocardial infarction rat models, we found that a combi...

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Veröffentlicht in:	Molecular and cellular biochemistry 2017-07, Vol.431 (1-2), p.151-160
Hauptverfasser:	Sun, Jian, Wei, Tao, Bai, Shuzhi, Zhao, Hongtao, Liu, Xiaoqin, Yu, Jinfeng, Li, Li, Song, Gaochen, Luan, Hairong, Xu, Changqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Apoptosis Apoptosis Regulatory Proteins - biosynthesis BAX protein Bcl-2 protein Biochemistry Biomedical and Life Sciences Blood pressure Calcium Calcium-sensing receptors Cardiology Caspase Caspase-3 Caspase-9 Cell Line Detection Diastolic pressure Embryo cells Embryonic stem cells Extracellular signal-regulated kinase Falling Gene expression Gene Expression Regulation Heart Heart attack Heart attacks Heart diseases Heart hypertrophy Heterografts Hypertrophy Inhibitors Injuries Ischemia JNK protein Kinases Life Sciences Male MAP kinase MAP Kinase Signaling System Medical Biochemistry Mice Mitogens Mouse Embryonic Stem Cells - metabolism Mouse Embryonic Stem Cells - pathology Myocardial infarction Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardial Infarction - therapy Oncology p38 Protein Protein kinase Protein kinases Proteins Rats Rats, Wistar Receptors Receptors, Calcium-Sensing - antagonists & inhibitors Receptors, Calcium-Sensing - metabolism Receptors, G-Protein-Coupled - antagonists & inhibitors Receptors, G-Protein-Coupled - metabolism Reperfusion RNA Rodents Stem Cell Transplantation Stem cells Therapy Transplantation Transplants & implants Ventricle
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