Intramyocellular lipid accumulation and reduced whole body lipid oxidation in HIV lipodystrophy
Divisions of 4 Infectious Diseases, 5 Diagnostic Radiology, and 6 Nuclear Medicine, 2 Clinical Research Unit II, and 3 Clinical Spectroscopy Unit, San Raffaele Scientific Institute, and 1 International Center for Assessment of the Nutritional Status, Universita' degli Studi di Milano, 201...
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| Veröffentlicht in: | American journal of physiology: endocrinology and metabolism 2003-02, Vol.284 (2), p.E274-E280 |
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| container_title | American journal of physiology: endocrinology and metabolism |
| container_volume | 284 |
| creator | Luzi, Livio Perseghin, Gianluca Tambussi, Giuseppe Meneghini, Elena Scifo, Paola Pagliato, Emanuela Del Maschio, Alessandro Testolin, Giulio Lazzarin, Adriano |
| description | Divisions of 4 Infectious Diseases,
5 Diagnostic Radiology, and 6 Nuclear
Medicine, 2 Clinical Research Unit II, and
3 Clinical Spectroscopy Unit, San Raffaele Scientific
Institute, and 1 International Center for Assessment of
the Nutritional Status, Universita' degli Studi di Milano, 20132 Milan, Italy
Antiretroviral therapy in
human immunodeficiency virus (HIV)-positive patients can induce a
lipodystrophy syndrome of peripheral fat wasting and central adiposity,
dyslipidemia, and insulin resistance. To test whether in this syndrome
insulin resistance is associated with abnormal muscle handling of fatty
acids, 12 HIV-1 patients (8 females/4 males , age = 26 ± 2 yr, HIV duratio n = 8 ± 1 yr, body mass index = 22.0 ± 1.0 kg/m 2 , on protease inhibitors and
nucleoside analog RT inhibitors) and 12 healthy subjects were studied.
HIV-1 patients had a total body fat content (assessed by dual-energy
X-ray absorptiometry) similar to that of controls (22 ± 1 vs.
23 ± 2%; P = 0.56), with a topographic fat
redistribution characterized by reduced fat content in the legs
(18 ± 2 vs. 32 ± 3%; P |
| doi_str_mv | 10.1152/ajpendo.00391.2001 |
| format | Article |
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5 Diagnostic Radiology, and 6 Nuclear
Medicine, 2 Clinical Research Unit II, and
3 Clinical Spectroscopy Unit, San Raffaele Scientific
Institute, and 1 International Center for Assessment of
the Nutritional Status, Universita' degli Studi di Milano, 20132 Milan, Italy
Antiretroviral therapy in
human immunodeficiency virus (HIV)-positive patients can induce a
lipodystrophy syndrome of peripheral fat wasting and central adiposity,
dyslipidemia, and insulin resistance. To test whether in this syndrome
insulin resistance is associated with abnormal muscle handling of fatty
acids, 12 HIV-1 patients (8 females/4 males , age = 26 ± 2 yr, HIV duratio n = 8 ± 1 yr, body mass index = 22.0 ± 1.0 kg/m 2 , on protease inhibitors and
nucleoside analog RT inhibitors) and 12 healthy subjects were studied.
HIV-1 patients had a total body fat content (assessed by dual-energy
X-ray absorptiometry) similar to that of controls (22 ± 1 vs.
23 ± 2%; P = 0.56), with a topographic fat
redistribution characterized by reduced fat content in the legs
(18 ± 2 vs. 32 ± 3%; P < 0.01) and
increased fat content in the trunk (25 ± 2 vs. 19 ± 2%;
P = 0.03). In HIV-positive patients, insulin
sensitivity (assessed by QUICKI) was markedly impaired (0.341 ± 0.011 vs. 0.376 ± 0.007; P = 0.012). HIV-positive patients also had increased total plasma cholesterol (216 ± 20 vs. 174 ± 9 mg/dl; P = 0.05) and triglyceride
(298 ± 96 vs. 87 ± 11 mg/dl; P = 0.03)
concentrations. Muscular triglyceride content assessed by means of
1 H NMR spectroscopy was higher in HIV patients in soleus
[92 ± 12 vs. 42 ± 5 arbitrary units (AU);
P < 0.01] and tibialis anterior (26 ± 6 vs.
11 ± 3 AU; P = 0.04) muscles; in a stepwise
regression analysis, it was strongly associated with QUICKI
( R 2 = 0.27; P < 0.0093).
Even if the basal metabolic rate (assessed by indirect calorimetry) was
comparable to that of normal subjects, postabsorptive lipid oxidation
was significantly impaired (0.30 ± 0.07 vs. 0.88 ± 0.09 mg · kg 1 · min 1 ;
P < 0.01). In conclusion, lipodystrophy in HIV-1
patients in antiretroviral treatment is associated with intramuscular
fat accumulation, which may mediate the development of the insulin resistance syndrome.
human immunodeficiency virus</description><identifier>ISSN: 0193-1849</identifier><identifier>EISSN: 1522-1555</identifier><identifier>DOI: 10.1152/ajpendo.00391.2001</identifier><identifier>PMID: 12388139</identifier><language>eng</language><publisher>United States</publisher><subject>Adipose Tissue - metabolism ; Adult ; Body Composition ; Calorimetry, Indirect ; Cell Respiration ; Energy Metabolism ; Female ; HIV-1 ; HIV-Associated Lipodystrophy Syndrome - metabolism ; Humans ; Insulin Resistance ; Magnetic Resonance Spectroscopy ; Male ; Oxidation-Reduction ; Triglycerides - metabolism</subject><ispartof>American journal of physiology: endocrinology and metabolism, 2003-02, Vol.284 (2), p.E274-E280</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-27b30f485a6da1c62a0489f51446621e08f984dc09e2d252786371a3fca1c4803</citedby><cites>FETCH-LOGICAL-c418t-27b30f485a6da1c62a0489f51446621e08f984dc09e2d252786371a3fca1c4803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12388139$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luzi, Livio</creatorcontrib><creatorcontrib>Perseghin, Gianluca</creatorcontrib><creatorcontrib>Tambussi, Giuseppe</creatorcontrib><creatorcontrib>Meneghini, Elena</creatorcontrib><creatorcontrib>Scifo, Paola</creatorcontrib><creatorcontrib>Pagliato, Emanuela</creatorcontrib><creatorcontrib>Del Maschio, Alessandro</creatorcontrib><creatorcontrib>Testolin, Giulio</creatorcontrib><creatorcontrib>Lazzarin, Adriano</creatorcontrib><title>Intramyocellular lipid accumulation and reduced whole body lipid oxidation in HIV lipodystrophy</title><title>American journal of physiology: endocrinology and metabolism</title><addtitle>Am J Physiol Endocrinol Metab</addtitle><description>Divisions of 4 Infectious Diseases,
5 Diagnostic Radiology, and 6 Nuclear
Medicine, 2 Clinical Research Unit II, and
3 Clinical Spectroscopy Unit, San Raffaele Scientific
Institute, and 1 International Center for Assessment of
the Nutritional Status, Universita' degli Studi di Milano, 20132 Milan, Italy
Antiretroviral therapy in
human immunodeficiency virus (HIV)-positive patients can induce a
lipodystrophy syndrome of peripheral fat wasting and central adiposity,
dyslipidemia, and insulin resistance. To test whether in this syndrome
insulin resistance is associated with abnormal muscle handling of fatty
acids, 12 HIV-1 patients (8 females/4 males , age = 26 ± 2 yr, HIV duratio n = 8 ± 1 yr, body mass index = 22.0 ± 1.0 kg/m 2 , on protease inhibitors and
nucleoside analog RT inhibitors) and 12 healthy subjects were studied.
HIV-1 patients had a total body fat content (assessed by dual-energy
X-ray absorptiometry) similar to that of controls (22 ± 1 vs.
23 ± 2%; P = 0.56), with a topographic fat
redistribution characterized by reduced fat content in the legs
(18 ± 2 vs. 32 ± 3%; P < 0.01) and
increased fat content in the trunk (25 ± 2 vs. 19 ± 2%;
P = 0.03). In HIV-positive patients, insulin
sensitivity (assessed by QUICKI) was markedly impaired (0.341 ± 0.011 vs. 0.376 ± 0.007; P = 0.012). HIV-positive patients also had increased total plasma cholesterol (216 ± 20 vs. 174 ± 9 mg/dl; P = 0.05) and triglyceride
(298 ± 96 vs. 87 ± 11 mg/dl; P = 0.03)
concentrations. Muscular triglyceride content assessed by means of
1 H NMR spectroscopy was higher in HIV patients in soleus
[92 ± 12 vs. 42 ± 5 arbitrary units (AU);
P < 0.01] and tibialis anterior (26 ± 6 vs.
11 ± 3 AU; P = 0.04) muscles; in a stepwise
regression analysis, it was strongly associated with QUICKI
( R 2 = 0.27; P < 0.0093).
Even if the basal metabolic rate (assessed by indirect calorimetry) was
comparable to that of normal subjects, postabsorptive lipid oxidation
was significantly impaired (0.30 ± 0.07 vs. 0.88 ± 0.09 mg · kg 1 · min 1 ;
P < 0.01). In conclusion, lipodystrophy in HIV-1
patients in antiretroviral treatment is associated with intramuscular
fat accumulation, which may mediate the development of the insulin resistance syndrome.
human immunodeficiency virus</description><subject>Adipose Tissue - metabolism</subject><subject>Adult</subject><subject>Body Composition</subject><subject>Calorimetry, Indirect</subject><subject>Cell Respiration</subject><subject>Energy Metabolism</subject><subject>Female</subject><subject>HIV-1</subject><subject>HIV-Associated Lipodystrophy Syndrome - metabolism</subject><subject>Humans</subject><subject>Insulin Resistance</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Oxidation-Reduction</subject><subject>Triglycerides - metabolism</subject><issn>0193-1849</issn><issn>1522-1555</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFu3CAURVHVqpmm_YEuKq-68wQe2MCyipJmpEjZpN0iBnCGCBsXbCX--zAdR1lVXSF45149DkJfCd4S0sCFfhzdYOMWYyrJFjAm79CmDKAmTdO8RxtMJK2JYPIMfcr5EWPMGwYf0RkBKgShcoPUbpiS7pdoXAhz0KkKfvS20sbMfblPPg6VHmyVnJ2Ns9XTIQZX7aNdVjI-e3vC_FDd7H4fn8s0TymOh-Uz-tDpkN2X9TxHv66v7i9v6tu7n7vLH7e1YURMNfA9xR0TjW6tJqYFjZmQXUMYa1sgDotOCmYNlg4sNMBFSznRtDOFZgLTc_T91Dum-Gd2eVK9z8c_6cHFOSsOkgMw_l-QCN5izkgB4QSaFHNOrlNj8r1OiyJYHf2r1b_6618d_ZfQt7V93vfOvkVW4QWQJ-DgHw5PPjlVJGUfQ3xY1PUcwr17nl6bQTAF6go4U6PtSrb-d_Z1mbcMfQG64ag6</recordid><startdate>20030201</startdate><enddate>20030201</enddate><creator>Luzi, Livio</creator><creator>Perseghin, Gianluca</creator><creator>Tambussi, Giuseppe</creator><creator>Meneghini, Elena</creator><creator>Scifo, Paola</creator><creator>Pagliato, Emanuela</creator><creator>Del Maschio, Alessandro</creator><creator>Testolin, Giulio</creator><creator>Lazzarin, Adriano</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20030201</creationdate><title>Intramyocellular lipid accumulation and reduced whole body lipid oxidation in HIV lipodystrophy</title><author>Luzi, Livio ; Perseghin, Gianluca ; Tambussi, Giuseppe ; Meneghini, Elena ; Scifo, Paola ; Pagliato, Emanuela ; Del Maschio, Alessandro ; Testolin, Giulio ; Lazzarin, Adriano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-27b30f485a6da1c62a0489f51446621e08f984dc09e2d252786371a3fca1c4803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adipose Tissue - metabolism</topic><topic>Adult</topic><topic>Body Composition</topic><topic>Calorimetry, Indirect</topic><topic>Cell Respiration</topic><topic>Energy Metabolism</topic><topic>Female</topic><topic>HIV-1</topic><topic>HIV-Associated Lipodystrophy Syndrome - metabolism</topic><topic>Humans</topic><topic>Insulin Resistance</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Oxidation-Reduction</topic><topic>Triglycerides - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luzi, Livio</creatorcontrib><creatorcontrib>Perseghin, Gianluca</creatorcontrib><creatorcontrib>Tambussi, Giuseppe</creatorcontrib><creatorcontrib>Meneghini, Elena</creatorcontrib><creatorcontrib>Scifo, Paola</creatorcontrib><creatorcontrib>Pagliato, Emanuela</creatorcontrib><creatorcontrib>Del Maschio, Alessandro</creatorcontrib><creatorcontrib>Testolin, Giulio</creatorcontrib><creatorcontrib>Lazzarin, Adriano</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology: endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luzi, Livio</au><au>Perseghin, Gianluca</au><au>Tambussi, Giuseppe</au><au>Meneghini, Elena</au><au>Scifo, Paola</au><au>Pagliato, Emanuela</au><au>Del Maschio, Alessandro</au><au>Testolin, Giulio</au><au>Lazzarin, Adriano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intramyocellular lipid accumulation and reduced whole body lipid oxidation in HIV lipodystrophy</atitle><jtitle>American journal of physiology: endocrinology and metabolism</jtitle><addtitle>Am J Physiol Endocrinol Metab</addtitle><date>2003-02-01</date><risdate>2003</risdate><volume>284</volume><issue>2</issue><spage>E274</spage><epage>E280</epage><pages>E274-E280</pages><issn>0193-1849</issn><eissn>1522-1555</eissn><abstract>Divisions of 4 Infectious Diseases,
5 Diagnostic Radiology, and 6 Nuclear
Medicine, 2 Clinical Research Unit II, and
3 Clinical Spectroscopy Unit, San Raffaele Scientific
Institute, and 1 International Center for Assessment of
the Nutritional Status, Universita' degli Studi di Milano, 20132 Milan, Italy
Antiretroviral therapy in
human immunodeficiency virus (HIV)-positive patients can induce a
lipodystrophy syndrome of peripheral fat wasting and central adiposity,
dyslipidemia, and insulin resistance. To test whether in this syndrome
insulin resistance is associated with abnormal muscle handling of fatty
acids, 12 HIV-1 patients (8 females/4 males , age = 26 ± 2 yr, HIV duratio n = 8 ± 1 yr, body mass index = 22.0 ± 1.0 kg/m 2 , on protease inhibitors and
nucleoside analog RT inhibitors) and 12 healthy subjects were studied.
HIV-1 patients had a total body fat content (assessed by dual-energy
X-ray absorptiometry) similar to that of controls (22 ± 1 vs.
23 ± 2%; P = 0.56), with a topographic fat
redistribution characterized by reduced fat content in the legs
(18 ± 2 vs. 32 ± 3%; P < 0.01) and
increased fat content in the trunk (25 ± 2 vs. 19 ± 2%;
P = 0.03). In HIV-positive patients, insulin
sensitivity (assessed by QUICKI) was markedly impaired (0.341 ± 0.011 vs. 0.376 ± 0.007; P = 0.012). HIV-positive patients also had increased total plasma cholesterol (216 ± 20 vs. 174 ± 9 mg/dl; P = 0.05) and triglyceride
(298 ± 96 vs. 87 ± 11 mg/dl; P = 0.03)
concentrations. Muscular triglyceride content assessed by means of
1 H NMR spectroscopy was higher in HIV patients in soleus
[92 ± 12 vs. 42 ± 5 arbitrary units (AU);
P < 0.01] and tibialis anterior (26 ± 6 vs.
11 ± 3 AU; P = 0.04) muscles; in a stepwise
regression analysis, it was strongly associated with QUICKI
( R 2 = 0.27; P < 0.0093).
Even if the basal metabolic rate (assessed by indirect calorimetry) was
comparable to that of normal subjects, postabsorptive lipid oxidation
was significantly impaired (0.30 ± 0.07 vs. 0.88 ± 0.09 mg · kg 1 · min 1 ;
P < 0.01). In conclusion, lipodystrophy in HIV-1
patients in antiretroviral treatment is associated with intramuscular
fat accumulation, which may mediate the development of the insulin resistance syndrome.
human immunodeficiency virus</abstract><cop>United States</cop><pmid>12388139</pmid><doi>10.1152/ajpendo.00391.2001</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0193-1849 |
| ispartof | American journal of physiology: endocrinology and metabolism, 2003-02, Vol.284 (2), p.E274-E280 |
| issn | 0193-1849 1522-1555 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_18760741 |
| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adipose Tissue - metabolism Adult Body Composition Calorimetry, Indirect Cell Respiration Energy Metabolism Female HIV-1 HIV-Associated Lipodystrophy Syndrome - metabolism Humans Insulin Resistance Magnetic Resonance Spectroscopy Male Oxidation-Reduction Triglycerides - metabolism |
| title | Intramyocellular lipid accumulation and reduced whole body lipid oxidation in HIV lipodystrophy |
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