Characterization of the toxicity, mutagenicity, and carcinogenicity of methacrylonitrile in F344 rats and B6C3F1 mice

Methacrylonitrile is an unsaturated aliphatic nitrile. It is widely used in the preparation of homopolymers and copolymers, elastomers, and plastics, and as a chemical intermediate in the preparation of acids, amides, amines, esters, and other nitriles. Methacrylonitrile was nominated for study by t...

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Veröffentlicht in:	Archives of toxicology 2003-04, Vol.77 (4), p.233-242
Hauptverfasser:	NYSKA, Abraham, GHANAYEM, Burhan I
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biological and medical sciences Biomarkers - analysis Body Weight - drug effects Carcinogens Carcinogens - toxicity Chemical and industrial products toxicology. Toxic occupational diseases Creatinine - urine Cytoplasm - drug effects Cytoplasm - pathology Dose-Response Relationship, Drug Environmental Exposure Female Genes Liver - drug effects Liver - pathology Male Medical sciences Methacrylates - administration & dosage Methacrylates - metabolism Methacrylates - toxicity Mice Mice, Inbred Strains Mutagens - toxicity Mutation Nitriles - administration & dosage Nitriles - metabolism Nitriles - toxicity Olfactory Mucosa - drug effects Olfactory Mucosa - pathology Rats Rats, Inbred F344 Rodents Toxicity Toxicity Tests Toxicology Vacuoles - drug effects Vacuoles - pathology Various organic compounds
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