Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease β-amyloid protein precursor: Effect of C-terminal truncation on production of β-amyloid protein

The β‐amyloid protein (Aβ) is derived by proteolytic processing of the amyloid protein precursor (APP). Cleavage of APP by β‐secretase generates a C‐terminal fragment (APP‐CTFβ), which is subsequently cleaved by γ‐secretase to produce Aβ. Our previous studies have shown that the proteasome can cleav...

Ausführliche Beschreibung