Masses of phosphorylated neurofilaments are associated with abnormal Golgi apparatus of anterior horn neurons of β, β′-iminodipropionitrile-intoxicated rats

The Golgi apparatus (GA) of anterior horn neurons of rats chronically intoxicated with β,β′‐iminodipropionitrile (IDPN) in drinking water was examined with an organelle‐specific antibody. The neuropile of the anterior horns contained the typical axonal spheroids associated with IDPN toxicity while t...

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Veröffentlicht in:	Neuropathology 2002-06, Vol.22 (2), p.61-65
Hauptverfasser:	Uesugi, Makoto, Okamoto, Koichi, Tanaka, Makoto, Gonatas, Nicholas K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anterior Horn Cells - drug effects Anterior Horn Cells - metabolism Anterior Horn Cells - ultrastructure Golgi apparatus Golgi Apparatus - metabolism Golgi Apparatus - pathology Golgi Apparatus - ultrastructure IDPN Immunohistochemistry Male MG 160 neurofilament Neurofilament Proteins - drug effects Neurofilament Proteins - metabolism Neurofilament Proteins - ultrastructure Neuropil - drug effects Neuropil - metabolism Neuropil - ultrastructure Nitriles - toxicity Nuclear Proteins - metabolism Phosphorylation Rats Rats, Wistar Receptors, Cell Surface - metabolism Receptors, Fibroblast Growth Factor Saccharomyces cerevisiae Proteins Sialoglycoproteins - metabolism spinal cord Transcription Factors
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