Onnamide F:  A New Nematocide from a Southern Australian Marine Sponge, Trachycladus laevispirulifer

A southern Australian marine sponge, Trachycladus laevispirulifer, has yielded a potent new nematocide with antifungal activity which has been identified as onnamide F (1). The structure for 1 was assigned by detailed spectroscopic analysis and chemical conversion to the methyl ester 2. Onnamide F c...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2001-05, Vol.64 (5), p.640-642
Hauptverfasser: VUONG, Dat, CAPON, Robert J., LACEY, Ernest, GILL, Jennifer H., HEILAND, Kirstin, FRIEDEL, Thomas
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container_issue 5
container_start_page 640
container_title Journal of natural products (Washington, D.C.)
container_volume 64
creator VUONG, Dat
CAPON, Robert J.
LACEY, Ernest
GILL, Jennifer H.
HEILAND, Kirstin
FRIEDEL, Thomas
description A southern Australian marine sponge, Trachycladus laevispirulifer, has yielded a potent new nematocide with antifungal activity which has been identified as onnamide F (1). The structure for 1 was assigned by detailed spectroscopic analysis and chemical conversion to the methyl ester 2. Onnamide F contains a common structural motif previously described in a number of natural products exhibiting interesting pharmacological activities, including the insect chemical defense agent pederin (3), and the sponge metabolites the onnamides, mycalamides, and theopederins.
doi_str_mv 10.1021/np000474b
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source MEDLINE; American Chemical Society Journals
subjects Animals
Antifungal Agents - pharmacology
Antinematodal Agents - chemistry
Antinematodal Agents - isolation & purification
Antinematodal Agents - toxicity
Australia
Biological and medical sciences
Chemical control
Control
Fundamental and applied biological sciences. Psychology
General pharmacology
Haemonchus - drug effects
Mass Spectrometry
Medical sciences
Microbial Sensitivity Tests
natural products
Onnamide F
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytopathology. Animal pests. Plant and forest protection
Porifera
Porifera - chemistry
Protozoa. Invertebrates
Pyrans - chemistry
Pyrans - isolation & purification
Pyrans - toxicity
Saccharomyces cerevisiae - drug effects
Tissue Extracts - chemistry
Tissue Extracts - toxicity
Trachycladus laevispirulifer
title Onnamide F:  A New Nematocide from a Southern Australian Marine Sponge, Trachycladus laevispirulifer
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