Multiple roles of COX-2 in tumor angiogenesis: a target for antiangiogenic therapy

Angiogenesis is required for multistage carcinogenesis. The inducible enzyme cyclooxygenase-2 (COX-2) is an important mediator of angiogenesis and tumor growth. COX-2 expression occurs in a wide range of preneoplastic and malignant conditions; and the enzyme has been localized to the neoplastic cell...

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Veröffentlicht in:Seminars in oncology 2004-04, Vol.31 (2 Suppl 7), p.2-11
Hauptverfasser: Gately, Stephen, Li, William W
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Sprache:eng
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