Expression of constitutively active Notch4 (Int-3) modulates myeloid proliferation and differentiation and promotes expansion of hematopoietic progenitors

The Notch family of transmembrane receptors has been implicated in the regulation of many developmental processes. In this study, we evaluated the role of Notch4 in immature hematopoietic progenitors by inducing, with retroviral transduction, enforced expression of Int-3, the oncogenic and constitut...

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Veröffentlicht in:	Leukemia 2004-04, Vol.18 (4), p.777-787
Hauptverfasser:	YE, Q, SHIEH, J-H, MORRONE, G, MOORE, M. A. S
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Acetic acid Animals Biological and medical sciences Biomarkers Bone marrow Cell cycle Cell differentiation Cell Differentiation - drug effects Cell Division Cell Line Clonal deletion Colony-forming cells Deletion mutant Differentiation Epidermal growth factor Growth rate Hematologic and hematopoietic diseases Hematopoietic stem cells Hematopoietic Stem Cells - cytology HL-60 Cells Humans Leukemia Ligands Medical sciences Mice Mice, Inbred BALB C Myeloid Cells Myeloid leukemia Myelopoiesis Phorbol Esters - pharmacology Progenitor cells Protein Structure, Tertiary Proteins Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - physiology Receptor, Notch4 Receptors, Cell Surface Receptors, Notch Retinoic acid Signal transduction Stem cell transplantation Stem cells Transfection Tretinoin - pharmacology Viruses
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