Hypoxia and inflammation indicate significant differences in the severity of obstructive sleep apnea within similar apnea-hypopnea index groups
Purpose We determined whether hypoxia parameters are associated with C-reactive protein (CRP), mean platelet volume (MPV), white matter hyperintensity (WMH), and the severity of obstructive sleep apnea (OSA), and also evaluated whether hypoxia parameters, CRP, MPV, and WMH differ in patients with si...
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| Veröffentlicht in: | Sleep & breathing 2017-09, Vol.21 (3), p.703-711 |
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| creator | Yilmaz Avci, Aynur Avci, Suat Lakadamyali, Huseyin Can, Ufuk |
| description | Purpose
We determined whether hypoxia parameters are associated with C-reactive protein (CRP), mean platelet volume (MPV), white matter hyperintensity (WMH), and the severity of obstructive sleep apnea (OSA), and also evaluated whether hypoxia parameters, CRP, MPV, and WMH differ in patients with similar apnea-hypopnea index (AHI) scores.
Methods
A total of 297 patients, who were evaluated using polysomnography, were assessed retrospectively. The measured hypoxia parameters included total sleep time with oxygen saturation |
| doi_str_mv | 10.1007/s11325-017-1486-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1875405553</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1935724051</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-65e49c37aa3466d08d10a779ef3e9e3914b170d4fd9658f10a612fd67fd406233</originalsourceid><addsrcrecordid>eNp1kcFu1DAQhi0EoqXwAFyQJS5cDLYTx8kRVUCRKnGBs-WNx7uuEjvYTuk-Ba_MbFMQQuLk8fzf_GP5J-Sl4G8F5_pdEaKRinGhmWj7jqlH5FwoKZnQfHh8X3M2KCHPyLNSbjhHahBPyZnspcZRfU5-Xh2XdBcstdHREP1k59nWkCJeXBhtBVrCPgaPdazUBe8hQxyhIEDrAWW4hRzqkSZP067UvI413GJ_AlioXSJY-iPUA-IlzGGyeWuyA26-V3ET3NF9TutSnpMn3k4FXjycF-Tbxw9fL6_Y9ZdPny_fX7Ox0bKyTkE7YGlt03ad470T3Go9gG9ggGYQ7Q7_wLXeDZ3qPYqdkN512ruWd7JpLsibzXfJ6fsKpZo5lBGmyUZIazGi16rlSqkT-vof9CatOeLrjBgapSVyAimxUWNOpWTwZslhtvloBDentMyWlsG0zCkto3Dm1YPzupvB_Zn4HQ8CcgMKSnEP-a_V_3X9BXhKods</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1935724051</pqid></control><display><type>article</type><title>Hypoxia and inflammation indicate significant differences in the severity of obstructive sleep apnea within similar apnea-hypopnea index groups</title><source>SpringerLink Journals - AutoHoldings</source><creator>Yilmaz Avci, Aynur ; Avci, Suat ; Lakadamyali, Huseyin ; Can, Ufuk</creator><creatorcontrib>Yilmaz Avci, Aynur ; Avci, Suat ; Lakadamyali, Huseyin ; Can, Ufuk</creatorcontrib><description><![CDATA[Purpose
We determined whether hypoxia parameters are associated with C-reactive protein (CRP), mean platelet volume (MPV), white matter hyperintensity (WMH), and the severity of obstructive sleep apnea (OSA), and also evaluated whether hypoxia parameters, CRP, MPV, and WMH differ in patients with similar apnea-hypopnea index (AHI) scores.
Methods
A total of 297 patients, who were evaluated using polysomnography, were assessed retrospectively. The measured hypoxia parameters included total sleep time with oxygen saturation <90% (ST
90
), percentage of cumulative time with oxygen saturation <90% (CT
90
), and lowest oxygen saturation (min SaO
2
). The patients were divided into subgroups according to their CT
90
values, and patients with different AHI severities were divided into subgroups according to their ST
90
and min SaO
2
levels.
Results
Hypoxia parameters are associated with CRP, MPV, WMH, and the severity of OSA (
P
< 0.05). The hypoxia parameters differed in all subgroup analyses of similar AHI groups (
P
< 0.001), and CRP differed only in severe OSA (
P
< 0.008,
P
< 0.001). In subgroup analyses of similar AHI groups, MPV and WMH were not significantly different (
P
> 0.05). Above the hypoxia threshold (CT
90
≥ 10%) of CRP, MPV increased significantly and the presence of WMH increased twofold.
Conclusions
These data suggest that increased hypoxia severity may mediate increased inflammation and activation of platelets and contribute to the pathogenesis of WMH in patients with OSA. In addition, patients with severe OSA may show significant variability in inflammation and vascular risk. Further prospective data are needed.]]></description><identifier>ISSN: 1520-9512</identifier><identifier>EISSN: 1522-1709</identifier><identifier>DOI: 10.1007/s11325-017-1486-5</identifier><identifier>PMID: 28271327</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Apnea ; C-reactive protein ; Dentistry ; Hypoxia ; Inflammation ; Insomnia ; Internal Medicine ; Medicine ; Medicine & Public Health ; Neurology ; Neurology • Original Article ; Otorhinolaryngology ; Oxygen ; Pediatrics ; Platelets ; Pneumology/Respiratory System ; Sleep ; Sleep apnea ; Sleep disorders ; Substantia alba</subject><ispartof>Sleep & breathing, 2017-09, Vol.21 (3), p.703-711</ispartof><rights>Springer-Verlag Berlin Heidelberg 2017</rights><rights>Sleep and Breathing is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-65e49c37aa3466d08d10a779ef3e9e3914b170d4fd9658f10a612fd67fd406233</citedby><cites>FETCH-LOGICAL-c372t-65e49c37aa3466d08d10a779ef3e9e3914b170d4fd9658f10a612fd67fd406233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11325-017-1486-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11325-017-1486-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28271327$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yilmaz Avci, Aynur</creatorcontrib><creatorcontrib>Avci, Suat</creatorcontrib><creatorcontrib>Lakadamyali, Huseyin</creatorcontrib><creatorcontrib>Can, Ufuk</creatorcontrib><title>Hypoxia and inflammation indicate significant differences in the severity of obstructive sleep apnea within similar apnea-hypopnea index groups</title><title>Sleep & breathing</title><addtitle>Sleep Breath</addtitle><addtitle>Sleep Breath</addtitle><description><![CDATA[Purpose
We determined whether hypoxia parameters are associated with C-reactive protein (CRP), mean platelet volume (MPV), white matter hyperintensity (WMH), and the severity of obstructive sleep apnea (OSA), and also evaluated whether hypoxia parameters, CRP, MPV, and WMH differ in patients with similar apnea-hypopnea index (AHI) scores.
Methods
A total of 297 patients, who were evaluated using polysomnography, were assessed retrospectively. The measured hypoxia parameters included total sleep time with oxygen saturation <90% (ST
90
), percentage of cumulative time with oxygen saturation <90% (CT
90
), and lowest oxygen saturation (min SaO
2
). The patients were divided into subgroups according to their CT
90
values, and patients with different AHI severities were divided into subgroups according to their ST
90
and min SaO
2
levels.
Results
Hypoxia parameters are associated with CRP, MPV, WMH, and the severity of OSA (
P
< 0.05). The hypoxia parameters differed in all subgroup analyses of similar AHI groups (
P
< 0.001), and CRP differed only in severe OSA (
P
< 0.008,
P
< 0.001). In subgroup analyses of similar AHI groups, MPV and WMH were not significantly different (
P
> 0.05). Above the hypoxia threshold (CT
90
≥ 10%) of CRP, MPV increased significantly and the presence of WMH increased twofold.
Conclusions
These data suggest that increased hypoxia severity may mediate increased inflammation and activation of platelets and contribute to the pathogenesis of WMH in patients with OSA. In addition, patients with severe OSA may show significant variability in inflammation and vascular risk. Further prospective data are needed.]]></description><subject>Apnea</subject><subject>C-reactive protein</subject><subject>Dentistry</subject><subject>Hypoxia</subject><subject>Inflammation</subject><subject>Insomnia</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurology</subject><subject>Neurology • Original Article</subject><subject>Otorhinolaryngology</subject><subject>Oxygen</subject><subject>Pediatrics</subject><subject>Platelets</subject><subject>Pneumology/Respiratory System</subject><subject>Sleep</subject><subject>Sleep apnea</subject><subject>Sleep disorders</subject><subject>Substantia alba</subject><issn>1520-9512</issn><issn>1522-1709</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kcFu1DAQhi0EoqXwAFyQJS5cDLYTx8kRVUCRKnGBs-WNx7uuEjvYTuk-Ba_MbFMQQuLk8fzf_GP5J-Sl4G8F5_pdEaKRinGhmWj7jqlH5FwoKZnQfHh8X3M2KCHPyLNSbjhHahBPyZnspcZRfU5-Xh2XdBcstdHREP1k59nWkCJeXBhtBVrCPgaPdazUBe8hQxyhIEDrAWW4hRzqkSZP067UvI413GJ_AlioXSJY-iPUA-IlzGGyeWuyA26-V3ET3NF9TutSnpMn3k4FXjycF-Tbxw9fL6_Y9ZdPny_fX7Ox0bKyTkE7YGlt03ad470T3Go9gG9ggGYQ7Q7_wLXeDZ3qPYqdkN512ruWd7JpLsibzXfJ6fsKpZo5lBGmyUZIazGi16rlSqkT-vof9CatOeLrjBgapSVyAimxUWNOpWTwZslhtvloBDentMyWlsG0zCkto3Dm1YPzupvB_Zn4HQ8CcgMKSnEP-a_V_3X9BXhKods</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Yilmaz Avci, Aynur</creator><creator>Avci, Suat</creator><creator>Lakadamyali, Huseyin</creator><creator>Can, Ufuk</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7T5</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2R</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20170901</creationdate><title>Hypoxia and inflammation indicate significant differences in the severity of obstructive sleep apnea within similar apnea-hypopnea index groups</title><author>Yilmaz Avci, Aynur ; Avci, Suat ; Lakadamyali, Huseyin ; Can, Ufuk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-65e49c37aa3466d08d10a779ef3e9e3914b170d4fd9658f10a612fd67fd406233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Apnea</topic><topic>C-reactive protein</topic><topic>Dentistry</topic><topic>Hypoxia</topic><topic>Inflammation</topic><topic>Insomnia</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurology</topic><topic>Neurology • Original Article</topic><topic>Otorhinolaryngology</topic><topic>Oxygen</topic><topic>Pediatrics</topic><topic>Platelets</topic><topic>Pneumology/Respiratory System</topic><topic>Sleep</topic><topic>Sleep apnea</topic><topic>Sleep disorders</topic><topic>Substantia alba</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yilmaz Avci, Aynur</creatorcontrib><creatorcontrib>Avci, Suat</creatorcontrib><creatorcontrib>Lakadamyali, Huseyin</creatorcontrib><creatorcontrib>Can, Ufuk</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Social Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Sleep & breathing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yilmaz Avci, Aynur</au><au>Avci, Suat</au><au>Lakadamyali, Huseyin</au><au>Can, Ufuk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypoxia and inflammation indicate significant differences in the severity of obstructive sleep apnea within similar apnea-hypopnea index groups</atitle><jtitle>Sleep & breathing</jtitle><stitle>Sleep Breath</stitle><addtitle>Sleep Breath</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>21</volume><issue>3</issue><spage>703</spage><epage>711</epage><pages>703-711</pages><issn>1520-9512</issn><eissn>1522-1709</eissn><abstract><![CDATA[Purpose
We determined whether hypoxia parameters are associated with C-reactive protein (CRP), mean platelet volume (MPV), white matter hyperintensity (WMH), and the severity of obstructive sleep apnea (OSA), and also evaluated whether hypoxia parameters, CRP, MPV, and WMH differ in patients with similar apnea-hypopnea index (AHI) scores.
Methods
A total of 297 patients, who were evaluated using polysomnography, were assessed retrospectively. The measured hypoxia parameters included total sleep time with oxygen saturation <90% (ST
90
), percentage of cumulative time with oxygen saturation <90% (CT
90
), and lowest oxygen saturation (min SaO
2
). The patients were divided into subgroups according to their CT
90
values, and patients with different AHI severities were divided into subgroups according to their ST
90
and min SaO
2
levels.
Results
Hypoxia parameters are associated with CRP, MPV, WMH, and the severity of OSA (
P
< 0.05). The hypoxia parameters differed in all subgroup analyses of similar AHI groups (
P
< 0.001), and CRP differed only in severe OSA (
P
< 0.008,
P
< 0.001). In subgroup analyses of similar AHI groups, MPV and WMH were not significantly different (
P
> 0.05). Above the hypoxia threshold (CT
90
≥ 10%) of CRP, MPV increased significantly and the presence of WMH increased twofold.
Conclusions
These data suggest that increased hypoxia severity may mediate increased inflammation and activation of platelets and contribute to the pathogenesis of WMH in patients with OSA. In addition, patients with severe OSA may show significant variability in inflammation and vascular risk. Further prospective data are needed.]]></abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>28271327</pmid><doi>10.1007/s11325-017-1486-5</doi><tpages>9</tpages></addata></record> |
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| ispartof | Sleep & breathing, 2017-09, Vol.21 (3), p.703-711 |
| issn | 1520-9512 1522-1709 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1875405553 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Apnea C-reactive protein Dentistry Hypoxia Inflammation Insomnia Internal Medicine Medicine Medicine & Public Health Neurology Neurology • Original Article Otorhinolaryngology Oxygen Pediatrics Platelets Pneumology/Respiratory System Sleep Sleep apnea Sleep disorders Substantia alba |
| title | Hypoxia and inflammation indicate significant differences in the severity of obstructive sleep apnea within similar apnea-hypopnea index groups |
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