S. mansoni-T. cruzi co-infection modulates arginase-1/iNOS expression, liver and heart disease in mice

Although Schistosoma species and Trypanosoma cruzi share common endemic areas, co-infections by these parasites remains overlooked. By using a murine model of S. mansoni and T. cruzi co-infection, we investigated if and to what extent these infections might interact to change the pathological outcom...

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Veröffentlicht in:	Nitric oxide 2017-06, Vol.66, p.43-52
Hauptverfasser:	Rodrigues, João Paulo Ferreira, Caldas, Ivo Santana, Gonçalves, Reggiani Vilela, Almeida, Leonardo Augusto, Souza, Raquel Lopes Martins, Novaes, Rômulo Dias
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginase - metabolism Chagas Disease - immunology Chagas Disease - metabolism Coinfection - immunology Coinfection - metabolism Cytokines - metabolism Disease Susceptibility Experimental pathology Hepatic granuloma Liver - metabolism Liver Diseases, Parasitic - metabolism Liver Diseases, Parasitic - parasitology Liver Diseases, Parasitic - pathology Mice Myocarditis Myocarditis - metabolism Myocarditis - parasitology Myocarditis - pathology Myocardium - metabolism Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase - metabolism Parasitic diseases Schistosoma mansoni - immunology Schistosomiasis mansoni - immunology Schistosomiasis mansoni - metabolism Trypanosoma cruzi - immunology
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