Monocyte Chemoattractant Protein-1 (MCP-1) as a Potential Therapeutic Target and a Noninvasive Biomarker of Liver Fibrosis Associated With Transient Myeloproliferative Disorder in Down Syndrome
Liver fibrosis is one of the common complications of transient myeloproliferative disorder (TMD) in Down syndrome (DS), but the exact molecular pathogenesis is largely unknown. We herein report a neonate of DS with liver fibrosis associated with TMD, in which we performed the serial profibrogenic cy...
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| Veröffentlicht in: | Journal of pediatric hematology/oncology 2017-07, Vol.39 (5), p.e285-e289 |
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| container_title | Journal of pediatric hematology/oncology |
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| creator | Kobayashi, Kenichiro Yoshioka, Takako Miyauchi, Jun Nakazawa, Atsuko Yamazaki, Shigeaki Ono, Hiromi Tatsuno, Michiko Iijima, Kenta Takahashi, Chiaki Okada, Yoko Teranishi, Kenji Matsunaga, Takaaki Matsushima, Chieko Inagaki, Mayo Suehiro, Minoru Suehiro, Saori Nishitani, Masahiko Kubota, Hirohito Iio, Jun Nishida, Yoshinobu Katayama, Tetsuo Takada, Narito Watanabe, Kentaro Yamamoto, Tetsuro Yasumizu, Ryoji Matsuoka, Kentaro Ohki, Kentaro Kiyokawa, Nobutaka Maihara, Toshiro Usami, Ikuya |
| description | Liver fibrosis is one of the common complications of transient myeloproliferative disorder (TMD) in Down syndrome (DS), but the exact molecular pathogenesis is largely unknown. We herein report a neonate of DS with liver fibrosis associated with TMD, in which we performed the serial profibrogenic cytokines analyses. We found the active monocyte chemoattractant protein-1 expression in the affected liver tissue and also found that both serum and urinary monocyte chemoattractant protein-1 concentrations are noninvasive biomarkers of liver fibrosis. We also showed a prospective of the future anticytokine therapy with herbal medicine for the liver fibrosis associated with TMD in DS. |
| doi_str_mv | 10.1097/MPH.0000000000000809 |
| format | Article |
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We herein report a neonate of DS with liver fibrosis associated with TMD, in which we performed the serial profibrogenic cytokines analyses. We found the active monocyte chemoattractant protein-1 expression in the affected liver tissue and also found that both serum and urinary monocyte chemoattractant protein-1 concentrations are noninvasive biomarkers of liver fibrosis. 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We herein report a neonate of DS with liver fibrosis associated with TMD, in which we performed the serial profibrogenic cytokines analyses. We found the active monocyte chemoattractant protein-1 expression in the affected liver tissue and also found that both serum and urinary monocyte chemoattractant protein-1 concentrations are noninvasive biomarkers of liver fibrosis. We also showed a prospective of the future anticytokine therapy with herbal medicine for the liver fibrosis associated with TMD in DS.</abstract><cop>United States</cop><pmid>28267084</pmid><doi>10.1097/MPH.0000000000000809</doi></addata></record> |
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| ispartof | Journal of pediatric hematology/oncology, 2017-07, Vol.39 (5), p.e285-e289 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Biomarkers Chemokine CCL2 - analysis Cytokines - analysis Diagnosis, Differential Down Syndrome - complications Humans Infant, Newborn Leukemoid Reaction - complications Liver - chemistry Liver - pathology Liver Cirrhosis - diagnosis Liver Cirrhosis - etiology |
| title | Monocyte Chemoattractant Protein-1 (MCP-1) as a Potential Therapeutic Target and a Noninvasive Biomarker of Liver Fibrosis Associated With Transient Myeloproliferative Disorder in Down Syndrome |
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