The Role of 18F-fluorodeoxyglucose Positron Emission Tomography-Computed Tomography for Predicting Pathologic Response After Induction Therapy for Thymic Epithelial Tumors
Background We investigated the role of 18 F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) in predicting the effect of induction therapy in patients with thymic epithelial tumors. Methods Fourteen patients with thymic epithelial tumors who underwent PET-CT before and af...
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| Veröffentlicht in: | World journal of surgery 2017-07, Vol.41 (7), p.1828-1833 |
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| creator | Fukumoto, Koichi Fukui, Takayuki Okasaka, Toshiki Kawaguchi, Koji Nakamura, Shota Hakiri, Shuhei Ozeki, Naoki Sugiyama, Tomoshi Kato, Katsuhiko Yokoi, Kohei |
| description | Background
We investigated the role of
18
F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) in predicting the effect of induction therapy in patients with thymic epithelial tumors.
Methods
Fourteen patients with thymic epithelial tumors who underwent PET-CT before and after induction therapy were retrospectively analyzed. The relationship between the change in the maximum standardized uptake value (SUV
max
) in PET-CT, the response evaluation criteria in solid tumors and the pathologic response (Ef0, no necrosis of tumor cells; Ef1, some necrosis of tumor cells with more than one-third of viable tumor cells; Ef2, less than one-third of tumor cells were viable; and Ef3, no tumor cells were viable) was analyzed.
Results
The study cohort consisted of 5 males and 9 females. Nine of the patients had thymoma, and 5 had thymic carcinoma. The induction therapy included chemotherapy in 9 cases, chemoradiation therapy in 4 cases and radiation therapy in 1 case. Among the 8 patients with a pathologic response of Ef0/1, 5 were clinically evaluated as having stable disease (SD), while 3 were found to have had a partial response (PR). The SUV
max
was elevated in 2 cases, unchanged in 1 and decreased in 5. On the other hand, 3 of the 6 patients with a pathologic response of Ef2, 3 were classified as having SD, while the other 3 had a PR. The SUV
max
decreased in all of the patients.
Conclusions
In comparison with CT, PET-CT seems to be useful for predicting the pathologic response to induction therapy in patients with thymic epithelial tumors. |
| doi_str_mv | 10.1007/s00268-017-3938-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_wiley</sourceid><recordid>TN_cdi_proquest_miscellaneous_1875141714</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1875141714</sourcerecordid><originalsourceid>FETCH-LOGICAL-p1261-43ed654e1c2e1446f1556116d83df5c35c913222b5028f41f2a91aed74cd6eea3</originalsourceid><addsrcrecordid>eNp1kcGO1DAQRC0EEsPAB3DzkUvAbSdO5riMZmDRSoyWII5WSDqJV0462ImWfBM_iUfZAxdO3WrVK6mrGHsL4j0IkX8IQkhdJALyRB1UkchnbAepkolUUj1nO6F0GndQL9mrEB5EFGqhd-xP2SO_J4ecWg7FOWndQp4apN9r55aaAvILBTt7GvlpsCHYuJQ0UOerqV-TIw3TMmPzz4235PnFY2Pr2Y4dv1RzT446W_N7DBON0fOmndHz27FZoubq2GNkN7Ts1yFqT5Ode3S2crxcBvLhNXvRVi7gm6e5Z9_Pp_L4Obn7-un2eHOXTCA1JKnCRmcpQi0R0lS3kGUaQDeFatqsVll9ACWl_JkJWbQptLI6QIVNntaNRqzUnr3bfCdPvxYMs4l_1-hcNSItwUCRZ5BCHvPds8MmfbQOVzN5O1R-NSDMtRWztWJi2ObaipHmx5dvH8-iULGJPZMbGyI2dujNAy1-jJ_9n1d_AXqwlgc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1875141714</pqid></control><display><type>article</type><title>The Role of 18F-fluorodeoxyglucose Positron Emission Tomography-Computed Tomography for Predicting Pathologic Response After Induction Therapy for Thymic Epithelial Tumors</title><source>Wiley Online Library Journals Frontfile Complete</source><source>SpringerLink Journals</source><creator>Fukumoto, Koichi ; Fukui, Takayuki ; Okasaka, Toshiki ; Kawaguchi, Koji ; Nakamura, Shota ; Hakiri, Shuhei ; Ozeki, Naoki ; Sugiyama, Tomoshi ; Kato, Katsuhiko ; Yokoi, Kohei</creator><creatorcontrib>Fukumoto, Koichi ; Fukui, Takayuki ; Okasaka, Toshiki ; Kawaguchi, Koji ; Nakamura, Shota ; Hakiri, Shuhei ; Ozeki, Naoki ; Sugiyama, Tomoshi ; Kato, Katsuhiko ; Yokoi, Kohei</creatorcontrib><description>Background
We investigated the role of
18
F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) in predicting the effect of induction therapy in patients with thymic epithelial tumors.
Methods
Fourteen patients with thymic epithelial tumors who underwent PET-CT before and after induction therapy were retrospectively analyzed. The relationship between the change in the maximum standardized uptake value (SUV
max
) in PET-CT, the response evaluation criteria in solid tumors and the pathologic response (Ef0, no necrosis of tumor cells; Ef1, some necrosis of tumor cells with more than one-third of viable tumor cells; Ef2, less than one-third of tumor cells were viable; and Ef3, no tumor cells were viable) was analyzed.
Results
The study cohort consisted of 5 males and 9 females. Nine of the patients had thymoma, and 5 had thymic carcinoma. The induction therapy included chemotherapy in 9 cases, chemoradiation therapy in 4 cases and radiation therapy in 1 case. Among the 8 patients with a pathologic response of Ef0/1, 5 were clinically evaluated as having stable disease (SD), while 3 were found to have had a partial response (PR). The SUV
max
was elevated in 2 cases, unchanged in 1 and decreased in 5. On the other hand, 3 of the 6 patients with a pathologic response of Ef2, 3 were classified as having SD, while the other 3 had a PR. The SUV
max
decreased in all of the patients.
Conclusions
In comparison with CT, PET-CT seems to be useful for predicting the pathologic response to induction therapy in patients with thymic epithelial tumors.</description><identifier>ISSN: 0364-2313</identifier><identifier>EISSN: 1432-2323</identifier><identifier>DOI: 10.1007/s00268-017-3938-2</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Abdominal Surgery ; Cardiac Surgery ; Chemoradiation Therapy ; General Surgery ; Induction Therapy ; Malignant Pleural Mesothelioma ; Medicine ; Medicine & Public Health ; Original Scientific Report ; Pathologic Response ; Surgery ; Thoracic Surgery ; Thymoma ; Vascular Surgery</subject><ispartof>World journal of surgery, 2017-07, Vol.41 (7), p.1828-1833</ispartof><rights>Société Internationale de Chirurgie 2017</rights><rights>2017 The Author(s) under exclusive licence to Société Internationale de Chirurgie</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-p1261-43ed654e1c2e1446f1556116d83df5c35c913222b5028f41f2a91aed74cd6eea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00268-017-3938-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00268-017-3938-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,41464,42533,45550,45551,51294</link.rule.ids></links><search><creatorcontrib>Fukumoto, Koichi</creatorcontrib><creatorcontrib>Fukui, Takayuki</creatorcontrib><creatorcontrib>Okasaka, Toshiki</creatorcontrib><creatorcontrib>Kawaguchi, Koji</creatorcontrib><creatorcontrib>Nakamura, Shota</creatorcontrib><creatorcontrib>Hakiri, Shuhei</creatorcontrib><creatorcontrib>Ozeki, Naoki</creatorcontrib><creatorcontrib>Sugiyama, Tomoshi</creatorcontrib><creatorcontrib>Kato, Katsuhiko</creatorcontrib><creatorcontrib>Yokoi, Kohei</creatorcontrib><title>The Role of 18F-fluorodeoxyglucose Positron Emission Tomography-Computed Tomography for Predicting Pathologic Response After Induction Therapy for Thymic Epithelial Tumors</title><title>World journal of surgery</title><addtitle>World J Surg</addtitle><description>Background
We investigated the role of
18
F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) in predicting the effect of induction therapy in patients with thymic epithelial tumors.
Methods
Fourteen patients with thymic epithelial tumors who underwent PET-CT before and after induction therapy were retrospectively analyzed. The relationship between the change in the maximum standardized uptake value (SUV
max
) in PET-CT, the response evaluation criteria in solid tumors and the pathologic response (Ef0, no necrosis of tumor cells; Ef1, some necrosis of tumor cells with more than one-third of viable tumor cells; Ef2, less than one-third of tumor cells were viable; and Ef3, no tumor cells were viable) was analyzed.
Results
The study cohort consisted of 5 males and 9 females. Nine of the patients had thymoma, and 5 had thymic carcinoma. The induction therapy included chemotherapy in 9 cases, chemoradiation therapy in 4 cases and radiation therapy in 1 case. Among the 8 patients with a pathologic response of Ef0/1, 5 were clinically evaluated as having stable disease (SD), while 3 were found to have had a partial response (PR). The SUV
max
was elevated in 2 cases, unchanged in 1 and decreased in 5. On the other hand, 3 of the 6 patients with a pathologic response of Ef2, 3 were classified as having SD, while the other 3 had a PR. The SUV
max
decreased in all of the patients.
Conclusions
In comparison with CT, PET-CT seems to be useful for predicting the pathologic response to induction therapy in patients with thymic epithelial tumors.</description><subject>Abdominal Surgery</subject><subject>Cardiac Surgery</subject><subject>Chemoradiation Therapy</subject><subject>General Surgery</subject><subject>Induction Therapy</subject><subject>Malignant Pleural Mesothelioma</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Scientific Report</subject><subject>Pathologic Response</subject><subject>Surgery</subject><subject>Thoracic Surgery</subject><subject>Thymoma</subject><subject>Vascular Surgery</subject><issn>0364-2313</issn><issn>1432-2323</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kcGO1DAQRC0EEsPAB3DzkUvAbSdO5riMZmDRSoyWII5WSDqJV0462ImWfBM_iUfZAxdO3WrVK6mrGHsL4j0IkX8IQkhdJALyRB1UkchnbAepkolUUj1nO6F0GndQL9mrEB5EFGqhd-xP2SO_J4ecWg7FOWndQp4apN9r55aaAvILBTt7GvlpsCHYuJQ0UOerqV-TIw3TMmPzz4235PnFY2Pr2Y4dv1RzT446W_N7DBON0fOmndHz27FZoubq2GNkN7Ts1yFqT5Ode3S2crxcBvLhNXvRVi7gm6e5Z9_Pp_L4Obn7-un2eHOXTCA1JKnCRmcpQi0R0lS3kGUaQDeFatqsVll9ACWl_JkJWbQptLI6QIVNntaNRqzUnr3bfCdPvxYMs4l_1-hcNSItwUCRZ5BCHvPds8MmfbQOVzN5O1R-NSDMtRWztWJi2ObaipHmx5dvH8-iULGJPZMbGyI2dujNAy1-jJ_9n1d_AXqwlgc</recordid><startdate>201707</startdate><enddate>201707</enddate><creator>Fukumoto, Koichi</creator><creator>Fukui, Takayuki</creator><creator>Okasaka, Toshiki</creator><creator>Kawaguchi, Koji</creator><creator>Nakamura, Shota</creator><creator>Hakiri, Shuhei</creator><creator>Ozeki, Naoki</creator><creator>Sugiyama, Tomoshi</creator><creator>Kato, Katsuhiko</creator><creator>Yokoi, Kohei</creator><general>Springer International Publishing</general><scope>7X8</scope></search><sort><creationdate>201707</creationdate><title>The Role of 18F-fluorodeoxyglucose Positron Emission Tomography-Computed Tomography for Predicting Pathologic Response After Induction Therapy for Thymic Epithelial Tumors</title><author>Fukumoto, Koichi ; Fukui, Takayuki ; Okasaka, Toshiki ; Kawaguchi, Koji ; Nakamura, Shota ; Hakiri, Shuhei ; Ozeki, Naoki ; Sugiyama, Tomoshi ; Kato, Katsuhiko ; Yokoi, Kohei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1261-43ed654e1c2e1446f1556116d83df5c35c913222b5028f41f2a91aed74cd6eea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Abdominal Surgery</topic><topic>Cardiac Surgery</topic><topic>Chemoradiation Therapy</topic><topic>General Surgery</topic><topic>Induction Therapy</topic><topic>Malignant Pleural Mesothelioma</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Scientific Report</topic><topic>Pathologic Response</topic><topic>Surgery</topic><topic>Thoracic Surgery</topic><topic>Thymoma</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fukumoto, Koichi</creatorcontrib><creatorcontrib>Fukui, Takayuki</creatorcontrib><creatorcontrib>Okasaka, Toshiki</creatorcontrib><creatorcontrib>Kawaguchi, Koji</creatorcontrib><creatorcontrib>Nakamura, Shota</creatorcontrib><creatorcontrib>Hakiri, Shuhei</creatorcontrib><creatorcontrib>Ozeki, Naoki</creatorcontrib><creatorcontrib>Sugiyama, Tomoshi</creatorcontrib><creatorcontrib>Kato, Katsuhiko</creatorcontrib><creatorcontrib>Yokoi, Kohei</creatorcontrib><collection>MEDLINE - Academic</collection><jtitle>World journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fukumoto, Koichi</au><au>Fukui, Takayuki</au><au>Okasaka, Toshiki</au><au>Kawaguchi, Koji</au><au>Nakamura, Shota</au><au>Hakiri, Shuhei</au><au>Ozeki, Naoki</au><au>Sugiyama, Tomoshi</au><au>Kato, Katsuhiko</au><au>Yokoi, Kohei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of 18F-fluorodeoxyglucose Positron Emission Tomography-Computed Tomography for Predicting Pathologic Response After Induction Therapy for Thymic Epithelial Tumors</atitle><jtitle>World journal of surgery</jtitle><stitle>World J Surg</stitle><date>2017-07</date><risdate>2017</risdate><volume>41</volume><issue>7</issue><spage>1828</spage><epage>1833</epage><pages>1828-1833</pages><issn>0364-2313</issn><eissn>1432-2323</eissn><abstract>Background
We investigated the role of
18
F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) in predicting the effect of induction therapy in patients with thymic epithelial tumors.
Methods
Fourteen patients with thymic epithelial tumors who underwent PET-CT before and after induction therapy were retrospectively analyzed. The relationship between the change in the maximum standardized uptake value (SUV
max
) in PET-CT, the response evaluation criteria in solid tumors and the pathologic response (Ef0, no necrosis of tumor cells; Ef1, some necrosis of tumor cells with more than one-third of viable tumor cells; Ef2, less than one-third of tumor cells were viable; and Ef3, no tumor cells were viable) was analyzed.
Results
The study cohort consisted of 5 males and 9 females. Nine of the patients had thymoma, and 5 had thymic carcinoma. The induction therapy included chemotherapy in 9 cases, chemoradiation therapy in 4 cases and radiation therapy in 1 case. Among the 8 patients with a pathologic response of Ef0/1, 5 were clinically evaluated as having stable disease (SD), while 3 were found to have had a partial response (PR). The SUV
max
was elevated in 2 cases, unchanged in 1 and decreased in 5. On the other hand, 3 of the 6 patients with a pathologic response of Ef2, 3 were classified as having SD, while the other 3 had a PR. The SUV
max
decreased in all of the patients.
Conclusions
In comparison with CT, PET-CT seems to be useful for predicting the pathologic response to induction therapy in patients with thymic epithelial tumors.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s00268-017-3938-2</doi><tpages>6</tpages></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete; SpringerLink Journals |
| subjects | Abdominal Surgery Cardiac Surgery Chemoradiation Therapy General Surgery Induction Therapy Malignant Pleural Mesothelioma Medicine Medicine & Public Health Original Scientific Report Pathologic Response Surgery Thoracic Surgery Thymoma Vascular Surgery |
| title | The Role of 18F-fluorodeoxyglucose Positron Emission Tomography-Computed Tomography for Predicting Pathologic Response After Induction Therapy for Thymic Epithelial Tumors |
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