Curcumin induces G2/M arrest, apoptosis, NF-κB inhibition, and expression of differentiation genes in thyroid carcinoma cells

Purpose The therapy of unresectable advanced thyroid carcinomas shows unfavorable outcome. Constitutive nuclear factor-κB (NF-κB) activation in thyroid carcinomas frequently contributes to therapeutic resistance; the radioiodine therapy often fails due to the loss of differentiated functions in adva...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 2017-07, Vol.143 (7), p.1143-1154
Hauptverfasser:	Schwertheim, Suzan, Wein, Frederik, Lennartz, Klaus, Worm, Karl, Schmid, Kurt Werner, Sheu-Grabellus, Sien-Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis - drug effects Blotting, Western Cancer Research Cell Cycle Checkpoints - drug effects Cell Line, Tumor Cell Proliferation - drug effects Curcumin - pharmacology Enzyme-Linked Immunosorbent Assay Gene Expression Profiling Hematology Humans Internal Medicine Medicine Medicine & Public Health NF-kappa B - antagonists & inhibitors Oncology Original Article – Cancer Research Real-Time Polymerase Chain Reaction Thyroid Neoplasms - pathology Transcriptome
Online-Zugang:	Volltext
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