Does long term colchicine prevent degradation of collagen fiber network in osteoarthritis?

Aim Several studies have shown that colchicine exhibits an improvement in the symptoms of knee osteoarthritis (OA) but its effect on disease progression is unknown. To clarify the mechanism of action this study was done to see if colchicine prevents degradation of collagen fiber network in OA by stu...

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Veröffentlicht in:	International journal of rheumatic diseases 2018-01, Vol.21 (1), p.114-117
Hauptverfasser:	Srivastava, Ragini, Das, Siddharth K., Goel, Gautam, Asthana, Akash, Agarwal, Girdhar G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - administration & dosage Analgesics Analgesics, Non-Narcotic - administration & dosage Antirheumatic Agents - administration & dosage Arthritis Biomarkers - blood Cartilage diseases Cartilage oligomeric matrix protein Cartilage Oligomeric Matrix Protein - blood Colchicine Colchicine - administration & dosage Collagen COMP Disease Progression Drug Administration Schedule Enzyme-Linked Immunosorbent Assay Fibrillar Collagens - metabolism Humans Knee Matrix protein Osteoarthritis Osteoarthritis - diagnosis Osteoarthritis - drug therapy Osteoarthritis - metabolism Paracetamol Proteoglycans Proteolysis Time Factors Treatment Outcome
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