A randomized, placebo‐controlled trial of beloranib for the treatment of hypothalamic injury‐associated obesity

Aims Hypothalamic injury‐associated obesity (HIAO) results from damage to the hypothalamus that often occurs with surgical removal/radiation therapy of tumours in the hypothalamic region, such as craniopharyngioma. There is currently no rigorously studied pharmaceutical treatment for the intractable...

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Veröffentlicht in:	Diabetes, obesity & metabolism obesity & metabolism, 2017-08, Vol.19 (8), p.1165-1170
Hauptverfasser:	Shoemaker, Ashley, Proietto, Joseph, Abuzzahab, M. Jennifer, Markovic, Tania, Malloy, Jaret, Kim, Dennis D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aminopeptidases - antagonists & inhibitors Aminopeptidases - metabolism antiobesity drug appetite control Appetite Depressants - administration & dosage Appetite Depressants - adverse effects Appetite Depressants - therapeutic use Biomarkers - blood Body Mass Index Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cardiovascular Diseases - prevention & control Cinnamates - administration & dosage Cinnamates - adverse effects Cinnamates - therapeutic use clinical trial Cohort Studies Cyclohexanes - administration & dosage Cyclohexanes - adverse effects Cyclohexanes - therapeutic use Double-Blind Method Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - adverse effects Enzyme Inhibitors - therapeutic use Epoxy Compounds - administration & dosage Epoxy Compounds - adverse effects Epoxy Compounds - therapeutic use Evidence-based medicine Female Follow-Up Studies Glycoproteins - antagonists & inhibitors Glycoproteins - metabolism Humans Hypothalamus - injuries Injections, Subcutaneous Male Metabolic Syndrome - epidemiology Metabolic Syndrome - etiology Metabolic Syndrome - prevention & control Obesity obesity therapy Obesity, Morbid - blood Obesity, Morbid - drug therapy Obesity, Morbid - etiology Obesity, Morbid - physiopathology phase I to II study Proof of Concept Study randomised trial Risk Sesquiterpenes - administration & dosage Sesquiterpenes - adverse effects Sesquiterpenes - therapeutic use Weight control Weight Loss - drug effects Young Adult
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