A Novel TRPM2 Isoform Inhibits Calcium Influx and Susceptibility to Cell Death

TRPM2 is a Ca2+-permeable channel that is activated by oxidative stress and confers susceptibility to cell death. Here, an isoform of TRPM2 was identified in normal human bone marrow that consists of the TRPM2 N terminus and the first two predicted transmembrane domains. Because of alternative splic...

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Veröffentlicht in:	The Journal of biological chemistry 2003-05, Vol.278 (18), p.16222-16229
Hauptverfasser:	Zhang, Wenyi, Chu, Xin, Tong, Qin, Cheung, Joseph Y., Conrad, Kathleen, Masker, Kathryn, Miller, Barbara A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Calcium - metabolism Calcium Channels - analysis Calcium Channels - physiology Cell Line Cloning, Molecular Humans Hydrogen Peroxide - pharmacology Ion Channels Membrane Proteins Protein Isoforms TRPM Cation Channels
Online-Zugang:	Volltext
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