The Impact of Bariatric Surgery on Thyroid Function and Medication Use in Patients with Hypothyroidism
Background Bariatric surgery (BS) is effective in treating obesity and its associated comorbidities. However, there is a paucity of data on the effect of BS on thyroid function in hypothyroid patients, specifically in those treated with thyroid hormone replacement therapy (THR). The aim of this stud...
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| Veröffentlicht in: | Obesity surgery 2017-08, Vol.27 (8), p.2000-2004 |
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| creator | Zendel, Alex Abu-Ghanem, Yasmin Dux, Joseph Mor, Eyal Zippel, Douglas Goitein, David |
| description | Background
Bariatric surgery (BS) is effective in treating obesity and its associated comorbidities. However, there is a paucity of data on the effect of BS on thyroid function in hypothyroid patients, specifically in those treated with thyroid hormone replacement therapy (THR). The aim of this study was to assess the effect of BS on thyroid function and on THR dosage in patients with hypothyroidism.
Methods
A retrospective analysis of prospectively collected data of all hypothyroid patients who underwent BS between 2010 and 2014 was performed. Data collected included demographic and anthropometric measurements, as well as changes in thyroid hormone levels and THR dosage up to a year from surgery.
Results
During the study period, 93 hypothyroid patients (85 females, 91%), 83 of which treated with replacement thyroid hormone, underwent BS. Laparoscopic sleeve gastrectomy was performed in 77 (82.8%) and Roux-en-Y gastric bypass in 16 patients. Average age and body mass index (BMI) were 46.6 ± 11.2 years and 43.7 ± 6.4 kg/m
2
, respectively. Mean BMI and thyroid-stimulating hormone (TSH) significantly deceased after 6 and 12 months following surgery whereas mean free T4 levels remained stable. TSH decrease was directly correlated to baseline TSH but not to BMI reduction. One year after surgery, 11 patients (13.2%) did not require THR, while the rest required a significantly lower average dose (
P
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| doi_str_mv | 10.1007/s11695-017-2616-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1874446315</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1918796249</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-407f07dda4bc5ddd1942763bf8334ba0d550e26ad617954e96c21556d1e3ac193</originalsourceid><addsrcrecordid>eNp1kU9rGzEQxUVpqZ20HyCXIuill000Wv1ZHdsQx4GEBmKfhSxpaxnvriPtEvztK2edEAI5DTP6vTdiHkJnQM6BEHmRAITiBQFZUAGikJ_QFCSpCsJo9RlNiRKkqBQtJ-gkpQ0hFASlX9GEVpTzisMU1Yu1xzfNztgedzX-Y2IwfQwWPwzxn4973LV4sd7HLjg8G1rbhzwwrcN33gVrnttl8ji0-D53vu0Tfgr9Gs_3u64fhSE139CX2myT_36sp2g5u1pczovbv9c3l79vC1tK2heMyJpI5wxbWe6cA8WoFOWqrsqSrQxxnBNPhXECpOLMK2EpcC4c-NJYUOUp-jX67mL3OPjU6yYk67db0_puSBoqyRgTJfCM_nyHbrohtvl3GlTmlKDsYAgjZWOXUvS13sXQmLjXQPQhBD2GoHMI-hCCllnz4-g8rBrvXhUvV88AHYGUn9p85jerP3T9D1bVkWA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1918796249</pqid></control><display><type>article</type><title>The Impact of Bariatric Surgery on Thyroid Function and Medication Use in Patients with Hypothyroidism</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Zendel, Alex ; Abu-Ghanem, Yasmin ; Dux, Joseph ; Mor, Eyal ; Zippel, Douglas ; Goitein, David</creator><creatorcontrib>Zendel, Alex ; Abu-Ghanem, Yasmin ; Dux, Joseph ; Mor, Eyal ; Zippel, Douglas ; Goitein, David</creatorcontrib><description>Background
Bariatric surgery (BS) is effective in treating obesity and its associated comorbidities. However, there is a paucity of data on the effect of BS on thyroid function in hypothyroid patients, specifically in those treated with thyroid hormone replacement therapy (THR). The aim of this study was to assess the effect of BS on thyroid function and on THR dosage in patients with hypothyroidism.
Methods
A retrospective analysis of prospectively collected data of all hypothyroid patients who underwent BS between 2010 and 2014 was performed. Data collected included demographic and anthropometric measurements, as well as changes in thyroid hormone levels and THR dosage up to a year from surgery.
Results
During the study period, 93 hypothyroid patients (85 females, 91%), 83 of which treated with replacement thyroid hormone, underwent BS. Laparoscopic sleeve gastrectomy was performed in 77 (82.8%) and Roux-en-Y gastric bypass in 16 patients. Average age and body mass index (BMI) were 46.6 ± 11.2 years and 43.7 ± 6.4 kg/m
2
, respectively. Mean BMI and thyroid-stimulating hormone (TSH) significantly deceased after 6 and 12 months following surgery whereas mean free T4 levels remained stable. TSH decrease was directly correlated to baseline TSH but not to BMI reduction. One year after surgery, 11 patients (13.2%) did not require THR, while the rest required a significantly lower average dose (
P
< 0.02).
Conclusions
There is a favorable effect of BS on the hypothyroid bariatric population. This includes improvement of thyroid function and reduction of thyroid medication dosages. Further studies are required to evaluate an influence of THR absorption and compare different types of bariatric surgeries.</description><identifier>ISSN: 0960-8923</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1007/s11695-017-2616-7</identifier><identifier>PMID: 28255851</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Aged ; Bariatric Surgery ; Comorbidity ; Dose-Response Relationship, Drug ; Drug use ; Female ; Gastrectomy - methods ; Gastric Bypass ; Gastrointestinal surgery ; Hormone Replacement Therapy ; Humans ; Hypothyroidism ; Hypothyroidism - drug therapy ; Hypothyroidism - epidemiology ; Hypothyroidism - physiopathology ; Laparoscopy ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Obesity ; Obesity - surgery ; Obesity, Morbid - physiopathology ; Obesity, Morbid - surgery ; Original Contributions ; Retrospective Studies ; Surgery ; Surgical outcomes ; Thyroid gland ; Thyroid Hormones - administration & dosage ; Thyroid Hormones - therapeutic use ; Thyrotropin ; Weight control ; Weight Loss ; Young Adult</subject><ispartof>Obesity surgery, 2017-08, Vol.27 (8), p.2000-2004</ispartof><rights>Springer Science+Business Media New York 2017</rights><rights>Obesity Surgery is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-407f07dda4bc5ddd1942763bf8334ba0d550e26ad617954e96c21556d1e3ac193</citedby><cites>FETCH-LOGICAL-c372t-407f07dda4bc5ddd1942763bf8334ba0d550e26ad617954e96c21556d1e3ac193</cites><orcidid>0000-0002-0570-8150</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11695-017-2616-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11695-017-2616-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28255851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zendel, Alex</creatorcontrib><creatorcontrib>Abu-Ghanem, Yasmin</creatorcontrib><creatorcontrib>Dux, Joseph</creatorcontrib><creatorcontrib>Mor, Eyal</creatorcontrib><creatorcontrib>Zippel, Douglas</creatorcontrib><creatorcontrib>Goitein, David</creatorcontrib><title>The Impact of Bariatric Surgery on Thyroid Function and Medication Use in Patients with Hypothyroidism</title><title>Obesity surgery</title><addtitle>OBES SURG</addtitle><addtitle>Obes Surg</addtitle><description>Background
Bariatric surgery (BS) is effective in treating obesity and its associated comorbidities. However, there is a paucity of data on the effect of BS on thyroid function in hypothyroid patients, specifically in those treated with thyroid hormone replacement therapy (THR). The aim of this study was to assess the effect of BS on thyroid function and on THR dosage in patients with hypothyroidism.
Methods
A retrospective analysis of prospectively collected data of all hypothyroid patients who underwent BS between 2010 and 2014 was performed. Data collected included demographic and anthropometric measurements, as well as changes in thyroid hormone levels and THR dosage up to a year from surgery.
Results
During the study period, 93 hypothyroid patients (85 females, 91%), 83 of which treated with replacement thyroid hormone, underwent BS. Laparoscopic sleeve gastrectomy was performed in 77 (82.8%) and Roux-en-Y gastric bypass in 16 patients. Average age and body mass index (BMI) were 46.6 ± 11.2 years and 43.7 ± 6.4 kg/m
2
, respectively. Mean BMI and thyroid-stimulating hormone (TSH) significantly deceased after 6 and 12 months following surgery whereas mean free T4 levels remained stable. TSH decrease was directly correlated to baseline TSH but not to BMI reduction. One year after surgery, 11 patients (13.2%) did not require THR, while the rest required a significantly lower average dose (
P
< 0.02).
Conclusions
There is a favorable effect of BS on the hypothyroid bariatric population. This includes improvement of thyroid function and reduction of thyroid medication dosages. Further studies are required to evaluate an influence of THR absorption and compare different types of bariatric surgeries.</description><subject>Adult</subject><subject>Aged</subject><subject>Bariatric Surgery</subject><subject>Comorbidity</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug use</subject><subject>Female</subject><subject>Gastrectomy - methods</subject><subject>Gastric Bypass</subject><subject>Gastrointestinal surgery</subject><subject>Hormone Replacement Therapy</subject><subject>Humans</subject><subject>Hypothyroidism</subject><subject>Hypothyroidism - drug therapy</subject><subject>Hypothyroidism - epidemiology</subject><subject>Hypothyroidism - physiopathology</subject><subject>Laparoscopy</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - surgery</subject><subject>Obesity, Morbid - physiopathology</subject><subject>Obesity, Morbid - surgery</subject><subject>Original Contributions</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Surgical outcomes</subject><subject>Thyroid gland</subject><subject>Thyroid Hormones - administration & dosage</subject><subject>Thyroid Hormones - therapeutic use</subject><subject>Thyrotropin</subject><subject>Weight control</subject><subject>Weight Loss</subject><subject>Young Adult</subject><issn>0960-8923</issn><issn>1708-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU9rGzEQxUVpqZ20HyCXIuill000Wv1ZHdsQx4GEBmKfhSxpaxnvriPtEvztK2edEAI5DTP6vTdiHkJnQM6BEHmRAITiBQFZUAGikJ_QFCSpCsJo9RlNiRKkqBQtJ-gkpQ0hFASlX9GEVpTzisMU1Yu1xzfNztgedzX-Y2IwfQwWPwzxn4973LV4sd7HLjg8G1rbhzwwrcN33gVrnttl8ji0-D53vu0Tfgr9Gs_3u64fhSE139CX2myT_36sp2g5u1pczovbv9c3l79vC1tK2heMyJpI5wxbWe6cA8WoFOWqrsqSrQxxnBNPhXECpOLMK2EpcC4c-NJYUOUp-jX67mL3OPjU6yYk67db0_puSBoqyRgTJfCM_nyHbrohtvl3GlTmlKDsYAgjZWOXUvS13sXQmLjXQPQhBD2GoHMI-hCCllnz4-g8rBrvXhUvV88AHYGUn9p85jerP3T9D1bVkWA</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Zendel, Alex</creator><creator>Abu-Ghanem, Yasmin</creator><creator>Dux, Joseph</creator><creator>Mor, Eyal</creator><creator>Zippel, Douglas</creator><creator>Goitein, David</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0570-8150</orcidid></search><sort><creationdate>20170801</creationdate><title>The Impact of Bariatric Surgery on Thyroid Function and Medication Use in Patients with Hypothyroidism</title><author>Zendel, Alex ; Abu-Ghanem, Yasmin ; Dux, Joseph ; Mor, Eyal ; Zippel, Douglas ; Goitein, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-407f07dda4bc5ddd1942763bf8334ba0d550e26ad617954e96c21556d1e3ac193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Bariatric Surgery</topic><topic>Comorbidity</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug use</topic><topic>Female</topic><topic>Gastrectomy - methods</topic><topic>Gastric Bypass</topic><topic>Gastrointestinal surgery</topic><topic>Hormone Replacement Therapy</topic><topic>Humans</topic><topic>Hypothyroidism</topic><topic>Hypothyroidism - drug therapy</topic><topic>Hypothyroidism - epidemiology</topic><topic>Hypothyroidism - physiopathology</topic><topic>Laparoscopy</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity - surgery</topic><topic>Obesity, Morbid - physiopathology</topic><topic>Obesity, Morbid - surgery</topic><topic>Original Contributions</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Surgical outcomes</topic><topic>Thyroid gland</topic><topic>Thyroid Hormones - administration & dosage</topic><topic>Thyroid Hormones - therapeutic use</topic><topic>Thyrotropin</topic><topic>Weight control</topic><topic>Weight Loss</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zendel, Alex</creatorcontrib><creatorcontrib>Abu-Ghanem, Yasmin</creatorcontrib><creatorcontrib>Dux, Joseph</creatorcontrib><creatorcontrib>Mor, Eyal</creatorcontrib><creatorcontrib>Zippel, Douglas</creatorcontrib><creatorcontrib>Goitein, David</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zendel, Alex</au><au>Abu-Ghanem, Yasmin</au><au>Dux, Joseph</au><au>Mor, Eyal</au><au>Zippel, Douglas</au><au>Goitein, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Impact of Bariatric Surgery on Thyroid Function and Medication Use in Patients with Hypothyroidism</atitle><jtitle>Obesity surgery</jtitle><stitle>OBES SURG</stitle><addtitle>Obes Surg</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>27</volume><issue>8</issue><spage>2000</spage><epage>2004</epage><pages>2000-2004</pages><issn>0960-8923</issn><eissn>1708-0428</eissn><abstract>Background
Bariatric surgery (BS) is effective in treating obesity and its associated comorbidities. However, there is a paucity of data on the effect of BS on thyroid function in hypothyroid patients, specifically in those treated with thyroid hormone replacement therapy (THR). The aim of this study was to assess the effect of BS on thyroid function and on THR dosage in patients with hypothyroidism.
Methods
A retrospective analysis of prospectively collected data of all hypothyroid patients who underwent BS between 2010 and 2014 was performed. Data collected included demographic and anthropometric measurements, as well as changes in thyroid hormone levels and THR dosage up to a year from surgery.
Results
During the study period, 93 hypothyroid patients (85 females, 91%), 83 of which treated with replacement thyroid hormone, underwent BS. Laparoscopic sleeve gastrectomy was performed in 77 (82.8%) and Roux-en-Y gastric bypass in 16 patients. Average age and body mass index (BMI) were 46.6 ± 11.2 years and 43.7 ± 6.4 kg/m
2
, respectively. Mean BMI and thyroid-stimulating hormone (TSH) significantly deceased after 6 and 12 months following surgery whereas mean free T4 levels remained stable. TSH decrease was directly correlated to baseline TSH but not to BMI reduction. One year after surgery, 11 patients (13.2%) did not require THR, while the rest required a significantly lower average dose (
P
< 0.02).
Conclusions
There is a favorable effect of BS on the hypothyroid bariatric population. This includes improvement of thyroid function and reduction of thyroid medication dosages. Further studies are required to evaluate an influence of THR absorption and compare different types of bariatric surgeries.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28255851</pmid><doi>10.1007/s11695-017-2616-7</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-0570-8150</orcidid></addata></record> |
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| subjects | Adult Aged Bariatric Surgery Comorbidity Dose-Response Relationship, Drug Drug use Female Gastrectomy - methods Gastric Bypass Gastrointestinal surgery Hormone Replacement Therapy Humans Hypothyroidism Hypothyroidism - drug therapy Hypothyroidism - epidemiology Hypothyroidism - physiopathology Laparoscopy Male Medicine Medicine & Public Health Middle Aged Obesity Obesity - surgery Obesity, Morbid - physiopathology Obesity, Morbid - surgery Original Contributions Retrospective Studies Surgery Surgical outcomes Thyroid gland Thyroid Hormones - administration & dosage Thyroid Hormones - therapeutic use Thyrotropin Weight control Weight Loss Young Adult |
| title | The Impact of Bariatric Surgery on Thyroid Function and Medication Use in Patients with Hypothyroidism |
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