Pathophysiology of Gastroesophageal Reflux Disease
Gastroesophageal reflux disease pathophysiology is multifactorial and linked to a misbalance between the aggressiveness of the refluxate into the esophagus or adjacent organs and the failure of protective mechanisms associate or not to a defective valvular mechanism at the level of the esophagogastr...
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| Veröffentlicht in: | World journal of surgery 2017-07, Vol.41 (7), p.1666-1671 |
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| container_title | World journal of surgery |
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| creator | Menezes, Mariano A. Herbella, Fernando A. M. |
| description | Gastroesophageal reflux disease pathophysiology is multifactorial and linked to a misbalance between the aggressiveness of the refluxate into the esophagus or adjacent organs and the failure of protective mechanisms associate or not to a defective valvular mechanism at the level of the esophagogastric junction incapable of dealing with a transdiaphragmatic pressure gradient. Antireflux mechanisms include the lower esophageal sphincter and abdominal esophagus, the diaphragm, the angle of His, the Gubaroff valve, and the phrenoesophageal membrane. Protective mechanisms include esophageal motility, saliva production, and epithelial protection. Disruption of this balance occurs most commonly due to the presence of a hiatal hernia, esophageal dysmotility, a rise in abdominal pressure (obesity), and decrease in thoracic pressure (chronic lung diseases). |
| doi_str_mv | 10.1007/s00268-017-3952-4 |
| format | Article |
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Disruption of this balance occurs most commonly due to the presence of a hiatal hernia, esophageal dysmotility, a rise in abdominal pressure (obesity), and decrease in thoracic pressure (chronic lung diseases).</description><identifier>ISSN: 0364-2313</identifier><identifier>EISSN: 1432-2323</identifier><identifier>DOI: 10.1007/s00268-017-3952-4</identifier><identifier>PMID: 28258452</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Abdominal Surgery ; Aggressive behavior ; Cardiac Surgery ; Diaphragm ; Diseases ; Disruption ; Esophageal Motility ; Esophageal sphincter ; Esophageal Sphincter, Lower - physiopathology ; Esophagogastric Junction ; Esophagogastric Junction - physiopathology ; Esophagus ; Failure ; Gastroesophageal reflux ; Gastroesophageal Reflux - etiology ; Gastroesophageal Reflux - physiopathology ; Gastroesophageal Reflux Disease ; General Surgery ; Hernia ; Hernia, Hiatal - physiopathology ; Hernias ; Hiatal Hernia ; Humans ; Lower Esophageal Sphincter ; Lung diseases ; Medicine ; Medicine & Public Health ; Obesity ; Organs ; Pressure ; Saliva ; Sphincter ; Surgery ; Surgical Symposium Contribution ; Thoracic Surgery ; Thorax ; Vascular Surgery</subject><ispartof>World journal of surgery, 2017-07, Vol.41 (7), p.1666-1671</ispartof><rights>Société Internationale de Chirurgie 2017</rights><rights>2017 The Author(s) under exclusive licence to Société Internationale de Chirurgie</rights><rights>World Journal of Surgery is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4225-a53cfd5fc630ff83b776a7a9700ba54573add94c5079db284830b6a607f7a3143</citedby><cites>FETCH-LOGICAL-c4225-a53cfd5fc630ff83b776a7a9700ba54573add94c5079db284830b6a607f7a3143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00268-017-3952-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00268-017-3952-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,41487,42556,45573,45574,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28258452$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Menezes, Mariano A.</creatorcontrib><creatorcontrib>Herbella, Fernando A. M.</creatorcontrib><title>Pathophysiology of Gastroesophageal Reflux Disease</title><title>World journal of surgery</title><addtitle>World J Surg</addtitle><addtitle>World J Surg</addtitle><description>Gastroesophageal reflux disease pathophysiology is multifactorial and linked to a misbalance between the aggressiveness of the refluxate into the esophagus or adjacent organs and the failure of protective mechanisms associate or not to a defective valvular mechanism at the level of the esophagogastric junction incapable of dealing with a transdiaphragmatic pressure gradient. Antireflux mechanisms include the lower esophageal sphincter and abdominal esophagus, the diaphragm, the angle of His, the Gubaroff valve, and the phrenoesophageal membrane. Protective mechanisms include esophageal motility, saliva production, and epithelial protection. Disruption of this balance occurs most commonly due to the presence of a hiatal hernia, esophageal dysmotility, a rise in abdominal pressure (obesity), and decrease in thoracic pressure (chronic lung diseases).</description><subject>Abdominal Surgery</subject><subject>Aggressive behavior</subject><subject>Cardiac Surgery</subject><subject>Diaphragm</subject><subject>Diseases</subject><subject>Disruption</subject><subject>Esophageal Motility</subject><subject>Esophageal sphincter</subject><subject>Esophageal Sphincter, Lower - physiopathology</subject><subject>Esophagogastric Junction</subject><subject>Esophagogastric Junction - physiopathology</subject><subject>Esophagus</subject><subject>Failure</subject><subject>Gastroesophageal reflux</subject><subject>Gastroesophageal Reflux - etiology</subject><subject>Gastroesophageal Reflux - physiopathology</subject><subject>Gastroesophageal Reflux Disease</subject><subject>General Surgery</subject><subject>Hernia</subject><subject>Hernia, Hiatal - physiopathology</subject><subject>Hernias</subject><subject>Hiatal Hernia</subject><subject>Humans</subject><subject>Lower Esophageal Sphincter</subject><subject>Lung diseases</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obesity</subject><subject>Organs</subject><subject>Pressure</subject><subject>Saliva</subject><subject>Sphincter</subject><subject>Surgery</subject><subject>Surgical Symposium Contribution</subject><subject>Thoracic Surgery</subject><subject>Thorax</subject><subject>Vascular Surgery</subject><issn>0364-2313</issn><issn>1432-2323</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkEtLAzEUhYMotlZ_gBspuHEzevPOLLXaqhQUH7gMmZmkHZk2ddJB--9NmSoiiKt7uXzncO5B6BDDKQaQZwGACJUAlglNOUnYFupiRklCKKHbqAtUsLhj2kF7IbxCBAWIXdQhinDFOOkicm-WU7-YrkLpKz9Z9b3rj0xY1t6GeDYTa6r-g3VV89G_LIM1we6jHWeqYA82s4eeh1dPg-tkfDe6GZyPk5wRwhPDae4K7nJBwTlFMymFkSaVAJnhjEtqiiJlOQeZFhlRTFHIhBEgnTQ0vtFDJ63vovZvjQ1LPStDbqvKzK1vgsZKMsbiH2lEj3-hr76p5zGdxikIyhVnECncUnntQ6it04u6nJl6pTHodaG6LVTHnvS6UL0OcbRxbrKZLb4VXw1GIG2B97Kyq_8d9cvt48UQFKU8akmrDVE2n9j6R-w_E30CzgOPYQ</recordid><startdate>201707</startdate><enddate>201707</enddate><creator>Menezes, Mariano A.</creator><creator>Herbella, Fernando A. M.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201707</creationdate><title>Pathophysiology of Gastroesophageal Reflux Disease</title><author>Menezes, Mariano A. ; Herbella, Fernando A. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4225-a53cfd5fc630ff83b776a7a9700ba54573add94c5079db284830b6a607f7a3143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Abdominal Surgery</topic><topic>Aggressive behavior</topic><topic>Cardiac Surgery</topic><topic>Diaphragm</topic><topic>Diseases</topic><topic>Disruption</topic><topic>Esophageal Motility</topic><topic>Esophageal sphincter</topic><topic>Esophageal Sphincter, Lower - physiopathology</topic><topic>Esophagogastric Junction</topic><topic>Esophagogastric Junction - physiopathology</topic><topic>Esophagus</topic><topic>Failure</topic><topic>Gastroesophageal reflux</topic><topic>Gastroesophageal Reflux - etiology</topic><topic>Gastroesophageal Reflux - physiopathology</topic><topic>Gastroesophageal Reflux Disease</topic><topic>General Surgery</topic><topic>Hernia</topic><topic>Hernia, Hiatal - physiopathology</topic><topic>Hernias</topic><topic>Hiatal Hernia</topic><topic>Humans</topic><topic>Lower Esophageal Sphincter</topic><topic>Lung diseases</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obesity</topic><topic>Organs</topic><topic>Pressure</topic><topic>Saliva</topic><topic>Sphincter</topic><topic>Surgery</topic><topic>Surgical Symposium Contribution</topic><topic>Thoracic Surgery</topic><topic>Thorax</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Menezes, Mariano A.</creatorcontrib><creatorcontrib>Herbella, Fernando A. 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Protective mechanisms include esophageal motility, saliva production, and epithelial protection. Disruption of this balance occurs most commonly due to the presence of a hiatal hernia, esophageal dysmotility, a rise in abdominal pressure (obesity), and decrease in thoracic pressure (chronic lung diseases).</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>28258452</pmid><doi>10.1007/s00268-017-3952-4</doi><tpages>6</tpages></addata></record> |
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| subjects | Abdominal Surgery Aggressive behavior Cardiac Surgery Diaphragm Diseases Disruption Esophageal Motility Esophageal sphincter Esophageal Sphincter, Lower - physiopathology Esophagogastric Junction Esophagogastric Junction - physiopathology Esophagus Failure Gastroesophageal reflux Gastroesophageal Reflux - etiology Gastroesophageal Reflux - physiopathology Gastroesophageal Reflux Disease General Surgery Hernia Hernia, Hiatal - physiopathology Hernias Hiatal Hernia Humans Lower Esophageal Sphincter Lung diseases Medicine Medicine & Public Health Obesity Organs Pressure Saliva Sphincter Surgery Surgical Symposium Contribution Thoracic Surgery Thorax Vascular Surgery |
| title | Pathophysiology of Gastroesophageal Reflux Disease |
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