Cancer stem cells: The root of tumor recurrence and metastases
Abstract Metastatic tumors are the cause of more than 90% of cancer related deaths. Metastasis formation can be considered as a culmination of the Darwinian evolutionary process within the tumor, when competition of multiple clones results in the development of cell inherent traits that favor tumor...
Gespeichert in:
| Veröffentlicht in: | Seminars in cancer biology 2017-06, Vol.44, p.10-24 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 24 |
|---|---|
| container_issue | |
| container_start_page | 10 |
| container_title | Seminars in cancer biology |
| container_volume | 44 |
| creator | Peitzsch, Claudia Tyutyunnykova, Anna Pantel, Klaus Dubrovska, Anna |
| description | Abstract Metastatic tumors are the cause of more than 90% of cancer related deaths. Metastasis formation can be considered as a culmination of the Darwinian evolutionary process within the tumor, when competition of multiple clones results in the development of cell inherent traits that favor tumor dissemination. Cancer stem cells (CSC) which possess self-renewal properties and genomic instability are considered to be an engine of tumor evolution. Cancer cells which have the capacity to colonize distant organs have the features of CSC and, in addition, exert their tumor-initiating capacity under adverse microenvironmental conditions. Recent studies support an idea that metastases can be driven by the evolved and selected subpopulations of CSC. In this review we discuss the common hallmarks of CSC and metastasis initiating cells (MIC) and prospects for the development of anti-metastatic therapy. |
| doi_str_mv | 10.1016/j.semcancer.2017.02.011 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1874445448</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S1044579X17300317</els_id><sourcerecordid>1874445448</sourcerecordid><originalsourceid>FETCH-LOGICAL-c492t-c49c07deba6260387e8f18c552c3c518ff7e02f6848cbb27dce24064d92f9eab3</originalsourceid><addsrcrecordid>eNqNkUtLxDAUhYMojq-_oFm6mXqTpk3qQpDBFwguVHAX0vQWO7aNJq0w_97U0Vm4EsJNCOecm3yXkBMGCQOWny2TgJ01vUWfcGAyAZ4AY1tkj0GRz9M8g-3pLMQ8k8XLjOyHsASAQjCxS2Zc8Xid5XvkYvEdQsOAHbXYtuGcPr0i9c4N1NV0GDvnqUc7eo9RSU1f0Q4HE-LCcEh2atMGPPrZD8jz9dXT4nZ-_3Bzt7i8n1tR8GGqFmSFpcl5DqmSqGqmbJZxm9qMqbqWCLzOlVC2LLmsLHIBuagKXhdoyvSAnK5z3737GDEMumvC9FzToxuDZkoKITIhVJTKtdR6F4LHWr_7pjN-pRnoCZ5e6g08PcHTwHWEF53HP03GssNq4_ulFQWXawHGr3420R5sM1Gpmkho0JVr_tHk4k-GbZu-saZ9wxWGpRt9H0lqpkM06MdphtMImUwB0li_AEJ7mTQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1874445448</pqid></control><display><type>article</type><title>Cancer stem cells: The root of tumor recurrence and metastases</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Peitzsch, Claudia ; Tyutyunnykova, Anna ; Pantel, Klaus ; Dubrovska, Anna</creator><creatorcontrib>Peitzsch, Claudia ; Tyutyunnykova, Anna ; Pantel, Klaus ; Dubrovska, Anna</creatorcontrib><description>Abstract Metastatic tumors are the cause of more than 90% of cancer related deaths. Metastasis formation can be considered as a culmination of the Darwinian evolutionary process within the tumor, when competition of multiple clones results in the development of cell inherent traits that favor tumor dissemination. Cancer stem cells (CSC) which possess self-renewal properties and genomic instability are considered to be an engine of tumor evolution. Cancer cells which have the capacity to colonize distant organs have the features of CSC and, in addition, exert their tumor-initiating capacity under adverse microenvironmental conditions. Recent studies support an idea that metastases can be driven by the evolved and selected subpopulations of CSC. In this review we discuss the common hallmarks of CSC and metastasis initiating cells (MIC) and prospects for the development of anti-metastatic therapy.</description><identifier>ISSN: 1044-579X</identifier><identifier>EISSN: 1096-3650</identifier><identifier>DOI: 10.1016/j.semcancer.2017.02.011</identifier><identifier>PMID: 28257956</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Cancer stem cells ; Cell Transformation, Neoplastic - genetics ; Cell Transformation, Neoplastic - pathology ; Circulating tumor cells ; Disseminated tumor cells ; Epithelial-mesenchymal transition ; Epithelial-Mesenchymal Transition - genetics ; Hematology, Oncology and Palliative Medicine ; Humans ; Metastasis-initiating cells ; Metastatic niche ; Neoplasm Metastasis ; Neoplasm Recurrence, Local - genetics ; Neoplasm Recurrence, Local - pathology ; Neoplasms - genetics ; Neoplasms - pathology ; Neoplastic Stem Cells</subject><ispartof>Seminars in cancer biology, 2017-06, Vol.44, p.10-24</ispartof><rights>Elsevier Ltd</rights><rights>2017 Elsevier Ltd</rights><rights>Copyright © 2017 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-c49c07deba6260387e8f18c552c3c518ff7e02f6848cbb27dce24064d92f9eab3</citedby><cites>FETCH-LOGICAL-c492t-c49c07deba6260387e8f18c552c3c518ff7e02f6848cbb27dce24064d92f9eab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1044579X17300317$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28257956$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peitzsch, Claudia</creatorcontrib><creatorcontrib>Tyutyunnykova, Anna</creatorcontrib><creatorcontrib>Pantel, Klaus</creatorcontrib><creatorcontrib>Dubrovska, Anna</creatorcontrib><title>Cancer stem cells: The root of tumor recurrence and metastases</title><title>Seminars in cancer biology</title><addtitle>Semin Cancer Biol</addtitle><description>Abstract Metastatic tumors are the cause of more than 90% of cancer related deaths. Metastasis formation can be considered as a culmination of the Darwinian evolutionary process within the tumor, when competition of multiple clones results in the development of cell inherent traits that favor tumor dissemination. Cancer stem cells (CSC) which possess self-renewal properties and genomic instability are considered to be an engine of tumor evolution. Cancer cells which have the capacity to colonize distant organs have the features of CSC and, in addition, exert their tumor-initiating capacity under adverse microenvironmental conditions. Recent studies support an idea that metastases can be driven by the evolved and selected subpopulations of CSC. In this review we discuss the common hallmarks of CSC and metastasis initiating cells (MIC) and prospects for the development of anti-metastatic therapy.</description><subject>Cancer stem cells</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Cell Transformation, Neoplastic - pathology</subject><subject>Circulating tumor cells</subject><subject>Disseminated tumor cells</subject><subject>Epithelial-mesenchymal transition</subject><subject>Epithelial-Mesenchymal Transition - genetics</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Metastasis-initiating cells</subject><subject>Metastatic niche</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Recurrence, Local - genetics</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - pathology</subject><subject>Neoplastic Stem Cells</subject><issn>1044-579X</issn><issn>1096-3650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtLxDAUhYMojq-_oFm6mXqTpk3qQpDBFwguVHAX0vQWO7aNJq0w_97U0Vm4EsJNCOecm3yXkBMGCQOWny2TgJ01vUWfcGAyAZ4AY1tkj0GRz9M8g-3pLMQ8k8XLjOyHsASAQjCxS2Zc8Xid5XvkYvEdQsOAHbXYtuGcPr0i9c4N1NV0GDvnqUc7eo9RSU1f0Q4HE-LCcEh2atMGPPrZD8jz9dXT4nZ-_3Bzt7i8n1tR8GGqFmSFpcl5DqmSqGqmbJZxm9qMqbqWCLzOlVC2LLmsLHIBuagKXhdoyvSAnK5z3737GDEMumvC9FzToxuDZkoKITIhVJTKtdR6F4LHWr_7pjN-pRnoCZ5e6g08PcHTwHWEF53HP03GssNq4_ulFQWXawHGr3420R5sM1Gpmkho0JVr_tHk4k-GbZu-saZ9wxWGpRt9H0lqpkM06MdphtMImUwB0li_AEJ7mTQ</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Peitzsch, Claudia</creator><creator>Tyutyunnykova, Anna</creator><creator>Pantel, Klaus</creator><creator>Dubrovska, Anna</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170601</creationdate><title>Cancer stem cells: The root of tumor recurrence and metastases</title><author>Peitzsch, Claudia ; Tyutyunnykova, Anna ; Pantel, Klaus ; Dubrovska, Anna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-c49c07deba6260387e8f18c552c3c518ff7e02f6848cbb27dce24064d92f9eab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Cancer stem cells</topic><topic>Cell Transformation, Neoplastic - genetics</topic><topic>Cell Transformation, Neoplastic - pathology</topic><topic>Circulating tumor cells</topic><topic>Disseminated tumor cells</topic><topic>Epithelial-mesenchymal transition</topic><topic>Epithelial-Mesenchymal Transition - genetics</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Metastasis-initiating cells</topic><topic>Metastatic niche</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Recurrence, Local - genetics</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - pathology</topic><topic>Neoplastic Stem Cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peitzsch, Claudia</creatorcontrib><creatorcontrib>Tyutyunnykova, Anna</creatorcontrib><creatorcontrib>Pantel, Klaus</creatorcontrib><creatorcontrib>Dubrovska, Anna</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Seminars in cancer biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peitzsch, Claudia</au><au>Tyutyunnykova, Anna</au><au>Pantel, Klaus</au><au>Dubrovska, Anna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cancer stem cells: The root of tumor recurrence and metastases</atitle><jtitle>Seminars in cancer biology</jtitle><addtitle>Semin Cancer Biol</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>44</volume><spage>10</spage><epage>24</epage><pages>10-24</pages><issn>1044-579X</issn><eissn>1096-3650</eissn><abstract>Abstract Metastatic tumors are the cause of more than 90% of cancer related deaths. Metastasis formation can be considered as a culmination of the Darwinian evolutionary process within the tumor, when competition of multiple clones results in the development of cell inherent traits that favor tumor dissemination. Cancer stem cells (CSC) which possess self-renewal properties and genomic instability are considered to be an engine of tumor evolution. Cancer cells which have the capacity to colonize distant organs have the features of CSC and, in addition, exert their tumor-initiating capacity under adverse microenvironmental conditions. Recent studies support an idea that metastases can be driven by the evolved and selected subpopulations of CSC. In this review we discuss the common hallmarks of CSC and metastasis initiating cells (MIC) and prospects for the development of anti-metastatic therapy.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>28257956</pmid><doi>10.1016/j.semcancer.2017.02.011</doi><tpages>15</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1044-579X |
| ispartof | Seminars in cancer biology, 2017-06, Vol.44, p.10-24 |
| issn | 1044-579X 1096-3650 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1874445448 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Cancer stem cells Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - pathology Circulating tumor cells Disseminated tumor cells Epithelial-mesenchymal transition Epithelial-Mesenchymal Transition - genetics Hematology, Oncology and Palliative Medicine Humans Metastasis-initiating cells Metastatic niche Neoplasm Metastasis Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Neoplasms - genetics Neoplasms - pathology Neoplastic Stem Cells |
| title | Cancer stem cells: The root of tumor recurrence and metastases |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T04%3A49%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cancer%20stem%20cells:%20The%20root%20of%20tumor%20recurrence%20and%20metastases&rft.jtitle=Seminars%20in%20cancer%20biology&rft.au=Peitzsch,%20Claudia&rft.date=2017-06-01&rft.volume=44&rft.spage=10&rft.epage=24&rft.pages=10-24&rft.issn=1044-579X&rft.eissn=1096-3650&rft_id=info:doi/10.1016/j.semcancer.2017.02.011&rft_dat=%3Cproquest_cross%3E1874445448%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1874445448&rft_id=info:pmid/28257956&rft_els_id=1_s2_0_S1044579X17300317&rfr_iscdi=true |