Synthesis and characterization of biodegradable poly(ether-ester) urethane acrylates for controlled drug release

Three polyether-ester triblock diols, with various molecular weights, were synthesized from ε-caprolactone and polyethylene glycol and used, with diisocyanates, as soft segments for the preparation of polyurethane acrylate oligomers. The polyurethane acrylates were used to generate cross-linked poly...

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Veröffentlicht in:	Materials Science & Engineering C 2017-05, Vol.74, p.270-278
Hauptverfasser:	Feng, Xuepeng, Wang, Guirong, Neumann, Kevin, Yao, Wei, Ding, Lin, Li, Songyan, Sheng, Yang, Jiang, Yan, Bradley, Mark, Zhang, Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylates Antibiotics Biodegradability Biodegradable Biodegradation Calorimetry, Differential Scanning Chemical synthesis Controlled drug release Crosslinking Delayed-Action Preparations - chemical synthesis Delayed-Action Preparations - chemistry Diisocyanates Diols Drug delivery systems Drug Liberation Elastic Modulus Escherichia coli - drug effects Ethylene Oxide - chemistry Hydrogen peroxide Hydrophobic and Hydrophilic Interactions Lactones - chemistry Lipase Magnetic Resonance Spectroscopy Materials science Microscopy, Electron, Scanning Oligomers Poly(ether-ester) Polyesters - chemistry Polyethylene glycol Polyethylenes Polymerization Polymerization - radiation effects Polymers Polyurethane Polyurethane acrylates Polyurethane resins Polyurethanes - chemical synthesis Polyurethanes - chemistry Tetracycline Tetracycline - chemistry Tetracycline - metabolism Tetracycline - pharmacology Ultraviolet Rays
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