Synthesis and characterization of biodegradable poly(ether-ester) urethane acrylates for controlled drug release
Three polyether-ester triblock diols, with various molecular weights, were synthesized from ε-caprolactone and polyethylene glycol and used, with diisocyanates, as soft segments for the preparation of polyurethane acrylate oligomers. The polyurethane acrylates were used to generate cross-linked poly...
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| Veröffentlicht in: | Materials Science & Engineering C 2017-05, Vol.74, p.270-278 |
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| creator | Feng, Xuepeng Wang, Guirong Neumann, Kevin Yao, Wei Ding, Lin Li, Songyan Sheng, Yang Jiang, Yan Bradley, Mark Zhang, Rong |
| description | Three polyether-ester triblock diols, with various molecular weights, were synthesized from ε-caprolactone and polyethylene glycol and used, with diisocyanates, as soft segments for the preparation of polyurethane acrylate oligomers. The polyurethane acrylates were used to generate cross-linked polyurethane films via UV initiated polymerization with and without cargo incorporation. Degradation experiment indicated that in PBS/H2O2/CoCl2 the films degraded rapidly compared to PBS alone or with lipase. The polyurethane membrane loaded with the antibiotic tetracycline, demonstrated prolonged release over 200h, suggesting that the polymers could be used as an implant coating for controlled drug release.
[Display omitted]
•Polymer diols based on PEG400 and poly(ε-caprolactone) were synthesized and used to make polyurethane acrylate (PUA) macro-monomers.•The PUA membranes were prepared by UV initiated polymerization and characterized with DSC, XRD, DMA and water contact angle measurement.•The biodegradation of the polyurethane membranes was carried out in PBS, lipase solution and H2O2 solution respectively.•The PUA membranes were loaded with tetracycline to evaluate the profiles of controlled drug release and were used for anti-bacteria test. |
| doi_str_mv | 10.1016/j.msec.2016.12.009 |
| format | Article |
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[Display omitted]
•Polymer diols based on PEG400 and poly(ε-caprolactone) were synthesized and used to make polyurethane acrylate (PUA) macro-monomers.•The PUA membranes were prepared by UV initiated polymerization and characterized with DSC, XRD, DMA and water contact angle measurement.•The biodegradation of the polyurethane membranes was carried out in PBS, lipase solution and H2O2 solution respectively.•The PUA membranes were loaded with tetracycline to evaluate the profiles of controlled drug release and were used for anti-bacteria test.</description><identifier>ISSN: 0928-4931</identifier><identifier>EISSN: 1873-0191</identifier><identifier>DOI: 10.1016/j.msec.2016.12.009</identifier><identifier>PMID: 28254295</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Acrylates ; Antibiotics ; Biodegradability ; Biodegradable ; Biodegradation ; Calorimetry, Differential Scanning ; Chemical synthesis ; Controlled drug release ; Crosslinking ; Delayed-Action Preparations - chemical synthesis ; Delayed-Action Preparations - chemistry ; Diisocyanates ; Diols ; Drug delivery systems ; Drug Liberation ; Elastic Modulus ; Escherichia coli - drug effects ; Ethylene Oxide - chemistry ; Hydrogen peroxide ; Hydrophobic and Hydrophilic Interactions ; Lactones - chemistry ; Lipase ; Magnetic Resonance Spectroscopy ; Materials science ; Microscopy, Electron, Scanning ; Oligomers ; Poly(ether-ester) ; Polyesters - chemistry ; Polyethylene glycol ; Polyethylenes ; Polymerization ; Polymerization - radiation effects ; Polymers ; Polyurethane ; Polyurethane acrylates ; Polyurethane resins ; Polyurethanes - chemical synthesis ; Polyurethanes - chemistry ; Tetracycline ; Tetracycline - chemistry ; Tetracycline - metabolism ; Tetracycline - pharmacology ; Ultraviolet Rays</subject><ispartof>Materials Science & Engineering C, 2017-05, Vol.74, p.270-278</ispartof><rights>2016 Elsevier B.V.</rights><rights>Copyright © 2016 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier BV May 1, 2017</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-a42ab3de9fb887ffdcd35b5552e1dab1f34bae6239f434fa353169e385cb85043</citedby><cites>FETCH-LOGICAL-c469t-a42ab3de9fb887ffdcd35b5552e1dab1f34bae6239f434fa353169e385cb85043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.msec.2016.12.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28254295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feng, Xuepeng</creatorcontrib><creatorcontrib>Wang, Guirong</creatorcontrib><creatorcontrib>Neumann, Kevin</creatorcontrib><creatorcontrib>Yao, Wei</creatorcontrib><creatorcontrib>Ding, Lin</creatorcontrib><creatorcontrib>Li, Songyan</creatorcontrib><creatorcontrib>Sheng, Yang</creatorcontrib><creatorcontrib>Jiang, Yan</creatorcontrib><creatorcontrib>Bradley, Mark</creatorcontrib><creatorcontrib>Zhang, Rong</creatorcontrib><title>Synthesis and characterization of biodegradable poly(ether-ester) urethane acrylates for controlled drug release</title><title>Materials Science & Engineering C</title><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><description>Three polyether-ester triblock diols, with various molecular weights, were synthesized from ε-caprolactone and polyethylene glycol and used, with diisocyanates, as soft segments for the preparation of polyurethane acrylate oligomers. The polyurethane acrylates were used to generate cross-linked polyurethane films via UV initiated polymerization with and without cargo incorporation. Degradation experiment indicated that in PBS/H2O2/CoCl2 the films degraded rapidly compared to PBS alone or with lipase. The polyurethane membrane loaded with the antibiotic tetracycline, demonstrated prolonged release over 200h, suggesting that the polymers could be used as an implant coating for controlled drug release.
[Display omitted]
•Polymer diols based on PEG400 and poly(ε-caprolactone) were synthesized and used to make polyurethane acrylate (PUA) macro-monomers.•The PUA membranes were prepared by UV initiated polymerization and characterized with DSC, XRD, DMA and water contact angle measurement.•The biodegradation of the polyurethane membranes was carried out in PBS, lipase solution and H2O2 solution respectively.•The PUA membranes were loaded with tetracycline to evaluate the profiles of controlled drug release and were used for anti-bacteria test.</description><subject>Acrylates</subject><subject>Antibiotics</subject><subject>Biodegradability</subject><subject>Biodegradable</subject><subject>Biodegradation</subject><subject>Calorimetry, Differential Scanning</subject><subject>Chemical synthesis</subject><subject>Controlled drug release</subject><subject>Crosslinking</subject><subject>Delayed-Action Preparations - chemical synthesis</subject><subject>Delayed-Action Preparations - chemistry</subject><subject>Diisocyanates</subject><subject>Diols</subject><subject>Drug delivery systems</subject><subject>Drug Liberation</subject><subject>Elastic Modulus</subject><subject>Escherichia coli - drug effects</subject><subject>Ethylene Oxide - chemistry</subject><subject>Hydrogen peroxide</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>Lactones - chemistry</subject><subject>Lipase</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Materials science</subject><subject>Microscopy, Electron, Scanning</subject><subject>Oligomers</subject><subject>Poly(ether-ester)</subject><subject>Polyesters - chemistry</subject><subject>Polyethylene glycol</subject><subject>Polyethylenes</subject><subject>Polymerization</subject><subject>Polymerization - radiation effects</subject><subject>Polymers</subject><subject>Polyurethane</subject><subject>Polyurethane acrylates</subject><subject>Polyurethane resins</subject><subject>Polyurethanes - chemical synthesis</subject><subject>Polyurethanes - chemistry</subject><subject>Tetracycline</subject><subject>Tetracycline - chemistry</subject><subject>Tetracycline - metabolism</subject><subject>Tetracycline - pharmacology</subject><subject>Ultraviolet Rays</subject><issn>0928-4931</issn><issn>1873-0191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUuLFDEUhYMoTjv6B1xIwM24qDLP6gq4GQZfMOBCXYdUcjOTJl1pb6qE9tebpkcXLryb3MB3Dod7CHnJWc8ZH97u-n0F34u291z0jJlHZMPHrewYN_wx2TAjxk4ZyS_Is1p3jA2j3Iqn5EKMQith9IYcvh7n5R5qqtTNgfp7h84vgOmXW1KZaYl0SiXAHbrgpgz0UPLxCpoEO6gNfENXbF83A3Uej9ktUGksSH2ZFyw5Q6AB1zuKkMFVeE6eRJcrvHh4L8n3D--_3Xzqbr98_Hxzfdt5NZilc0q4SQYwcRrHbYzBB6knrbUA3oLwKNXkYBDSRCVVdFJLPhiQo_bTqJmSl-Tq7HvA8mNtUe0-VQ85t6RlrbbdSbUxSjf09T_orqw4t3SWGyW2UismGiXOlMdSK0K0B0x7h0fLmT31YXf21Ic99WG5sK2PJnr1YL1Oewh_JX8KaMC7MwDtFj8ToK0-wewhJAS_2FDS__x_A0zLnfA</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Feng, Xuepeng</creator><creator>Wang, Guirong</creator><creator>Neumann, Kevin</creator><creator>Yao, Wei</creator><creator>Ding, Lin</creator><creator>Li, Songyan</creator><creator>Sheng, Yang</creator><creator>Jiang, Yan</creator><creator>Bradley, Mark</creator><creator>Zhang, Rong</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20170501</creationdate><title>Synthesis and characterization of biodegradable poly(ether-ester) urethane acrylates for controlled drug release</title><author>Feng, Xuepeng ; Wang, Guirong ; Neumann, Kevin ; Yao, Wei ; Ding, Lin ; Li, Songyan ; Sheng, Yang ; Jiang, Yan ; Bradley, Mark ; Zhang, Rong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-a42ab3de9fb887ffdcd35b5552e1dab1f34bae6239f434fa353169e385cb85043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acrylates</topic><topic>Antibiotics</topic><topic>Biodegradability</topic><topic>Biodegradable</topic><topic>Biodegradation</topic><topic>Calorimetry, Differential Scanning</topic><topic>Chemical synthesis</topic><topic>Controlled drug release</topic><topic>Crosslinking</topic><topic>Delayed-Action Preparations - chemical synthesis</topic><topic>Delayed-Action Preparations - chemistry</topic><topic>Diisocyanates</topic><topic>Diols</topic><topic>Drug delivery systems</topic><topic>Drug Liberation</topic><topic>Elastic Modulus</topic><topic>Escherichia coli - drug effects</topic><topic>Ethylene Oxide - chemistry</topic><topic>Hydrogen peroxide</topic><topic>Hydrophobic and Hydrophilic Interactions</topic><topic>Lactones - chemistry</topic><topic>Lipase</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Materials science</topic><topic>Microscopy, Electron, Scanning</topic><topic>Oligomers</topic><topic>Poly(ether-ester)</topic><topic>Polyesters - chemistry</topic><topic>Polyethylene glycol</topic><topic>Polyethylenes</topic><topic>Polymerization</topic><topic>Polymerization - radiation effects</topic><topic>Polymers</topic><topic>Polyurethane</topic><topic>Polyurethane acrylates</topic><topic>Polyurethane resins</topic><topic>Polyurethanes - chemical synthesis</topic><topic>Polyurethanes - 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Academic</collection><jtitle>Materials Science & Engineering C</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feng, Xuepeng</au><au>Wang, Guirong</au><au>Neumann, Kevin</au><au>Yao, Wei</au><au>Ding, Lin</au><au>Li, Songyan</au><au>Sheng, Yang</au><au>Jiang, Yan</au><au>Bradley, Mark</au><au>Zhang, Rong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and characterization of biodegradable poly(ether-ester) urethane acrylates for controlled drug release</atitle><jtitle>Materials Science & Engineering C</jtitle><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>74</volume><spage>270</spage><epage>278</epage><pages>270-278</pages><issn>0928-4931</issn><eissn>1873-0191</eissn><abstract>Three polyether-ester triblock diols, with various molecular weights, were synthesized from ε-caprolactone and polyethylene glycol and used, with diisocyanates, as soft segments for the preparation of polyurethane acrylate oligomers. The polyurethane acrylates were used to generate cross-linked polyurethane films via UV initiated polymerization with and without cargo incorporation. Degradation experiment indicated that in PBS/H2O2/CoCl2 the films degraded rapidly compared to PBS alone or with lipase. The polyurethane membrane loaded with the antibiotic tetracycline, demonstrated prolonged release over 200h, suggesting that the polymers could be used as an implant coating for controlled drug release.
[Display omitted]
•Polymer diols based on PEG400 and poly(ε-caprolactone) were synthesized and used to make polyurethane acrylate (PUA) macro-monomers.•The PUA membranes were prepared by UV initiated polymerization and characterized with DSC, XRD, DMA and water contact angle measurement.•The biodegradation of the polyurethane membranes was carried out in PBS, lipase solution and H2O2 solution respectively.•The PUA membranes were loaded with tetracycline to evaluate the profiles of controlled drug release and were used for anti-bacteria test.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28254295</pmid><doi>10.1016/j.msec.2016.12.009</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Acrylates Antibiotics Biodegradability Biodegradable Biodegradation Calorimetry, Differential Scanning Chemical synthesis Controlled drug release Crosslinking Delayed-Action Preparations - chemical synthesis Delayed-Action Preparations - chemistry Diisocyanates Diols Drug delivery systems Drug Liberation Elastic Modulus Escherichia coli - drug effects Ethylene Oxide - chemistry Hydrogen peroxide Hydrophobic and Hydrophilic Interactions Lactones - chemistry Lipase Magnetic Resonance Spectroscopy Materials science Microscopy, Electron, Scanning Oligomers Poly(ether-ester) Polyesters - chemistry Polyethylene glycol Polyethylenes Polymerization Polymerization - radiation effects Polymers Polyurethane Polyurethane acrylates Polyurethane resins Polyurethanes - chemical synthesis Polyurethanes - chemistry Tetracycline Tetracycline - chemistry Tetracycline - metabolism Tetracycline - pharmacology Ultraviolet Rays |
| title | Synthesis and characterization of biodegradable poly(ether-ester) urethane acrylates for controlled drug release |
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