Oncogenic role of microRNA‐155 in mycosis fungoides: an in vitro and xenograft mouse model study

Summary Background MicroRNA (miR)‐155 contributes to the proliferation of mycosis fungoides (MF) in vitro and is upregulated in tumours of MF compared with early MF lesions. Objectives To investigate the contribution of miR‐155 to the cancerous phenotype and drug resistance of MF/Sézary cell lines....

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Veröffentlicht in:	British journal of dermatology (1951) 2017-09, Vol.177 (3), p.791-800
Hauptverfasser:	Moyal, L., Yehezkel, S., Gorovitz, B., Keren, A., Gilhar, A., Lubin, I., Sherman, S., Hodak, E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Cell Cycle Checkpoints - drug effects Cell Line, Tumor Cell proliferation Drug resistance Female Flow cytometry Fungal infections Genes, cdc - drug effects HEK293 Cells Heterografts Histone Deacetylase Inhibitors - pharmacology Humans Hydroxamic acid Hydroxamic Acids - pharmacology Immune checkpoint Immunodeficiency In Vitro Techniques Lentivirus Mice, SCID MicroRNAs MicroRNAs - antagonists & inhibitors MicroRNAs - metabolism MicroRNAs - physiology miRNA Mycosis Mycosis fungoides Mycosis Fungoides - etiology Phenotype Plasmids Quinazolines - pharmacology Sezary Syndrome - etiology Skin Neoplasms - etiology Transduction, Genetic Transplantation, Heterologous Tumors Xenografts
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