Diagnostic and pathogenetic role of antineutrophil cytoplasmic autoantibodies
Anti-neutrophil cytoplasmic antibodies (ANCA) are mostly known as a useful diagnostic tool in patients with small-vessel vasculitides. With the accumulating knowledge of these autoantibodies, however, it becomes clear that the role of ANCA may not be only limited to a diagnosis of such disorders. Th...
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| Veröffentlicht in: | Clinical immunology (Orlando, Fla.) Fla.), 2003-02, Vol.106 (2), p.73-82 |
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| creator | BARTUONKOVA, Jirina TESAR, Vladimir SEDIVA, Anna |
| description | Anti-neutrophil cytoplasmic antibodies (ANCA) are mostly known as a useful diagnostic tool in patients with small-vessel vasculitides. With the accumulating knowledge of these autoantibodies, however, it becomes clear that the role of ANCA may not be only limited to a diagnosis of such disorders. The current review addresses, in addition to classical diagnostic associations, other diseases connected with ANCA positivity, both in adults and in children. The etiology of ANCA remains unknown, but still, the importance of both genetic and environmental factors is undoubted. The role of infection and chemicals in the etiology of ANCA-associated diseases is stressed in particular. A pathogenetic role of ANCA is suggested because of clinical observations based on the correlation of the vasculitis activity and the titer of ANCA. Many experiments show the effects of ANCA in various steps of an inflammatory process, particularly on leukocyte microbicidal activity and oxidative burst. Recent findings are analyzed in the experimental field and they are correlated with clinical significance. |
| doi_str_mv | 10.1016/S1521-6616(02)00026-8 |
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Recent findings are analyzed in the experimental field and they are correlated with clinical significance.</description><subject>Adult</subject><subject>Adults</subject><subject>Aged</subject><subject>Animals</subject><subject>Antibodies, Antineutrophil Cytoplasmic - analysis</subject><subject>Antibodies, Antineutrophil Cytoplasmic - immunology</subject><subject>Antimicrobial Cationic Peptides</subject><subject>Antineutrophil cytoplasmic antibodies</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Autoantigens - immunology</subject><subject>Autoimmune Diseases - chemically induced</subject><subject>Autoimmune Diseases - diagnosis</subject><subject>Autoimmune Diseases - genetics</subject><subject>Autoimmune Diseases - immunology</subject><subject>Biological and medical sciences</subject><subject>Blood Proteins - immunology</subject><subject>Cell Adhesion Molecules - physiology</subject><subject>Child</subject><subject>Children</subject><subject>Colitis, Ulcerative - immunology</subject><subject>Cystic Fibrosis - genetics</subject><subject>Cystic Fibrosis - immunology</subject><subject>Cytokines - physiology</subject><subject>Diagnostic association</subject><subject>Etiopathogenesis</subject><subject>General aspects</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Infection - complications</subject><subject>Medical sciences</subject><subject>Membrane Proteins</subject><subject>Mice</subject><subject>Middle Aged</subject><subject>Myeloblastin</subject><subject>Neutrophils - enzymology</subject><subject>Neutrophils - immunology</subject><subject>Neutrophils - pathology</subject><subject>Peroxidase - immunology</subject><subject>Respiratory Burst</subject><subject>Serine Endopeptidases - immunology</subject><subject>Silicosis - complications</subject><subject>Vasculitis - chemically induced</subject><subject>Vasculitis - diagnosis</subject><subject>Vasculitis - genetics</subject><subject>Vasculitis - immunology</subject><issn>1521-6616</issn><issn>1521-7035</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PxCAQhonRuLr6EzR70eihCrRQejJm_UzWeFDPhNJBMd1SgZrsv7fdbbJHTzOZed6BPAidEHxFMOHXb4RRknBO-AWmlxhjyhOxgw7W4xynbHfsB2SCDkP47iFGKd9HE0J5TtNCHKCXO6s-Gxei1TPVVLNWxS_3CQ0MA-9qmDnTL6JtoIvetV-2nulVdG2twnLIdNEN69JVFsIR2jOqDnA81in6eLh_nz8li9fH5_ntItGZEDExpaAYC8io4IALpnPODCOVplmBM2B5kRpCmcaZISVVvMBUqSrNS8WVwXmaTtH55m7r3U8HIcqlDRrqWjXguiCJyDPSX-9BtgG1dyF4MLL1dqn8ShIsB49y7VEOkiSmcu1RDrnT8YGuXEK1TY3ieuBsBFTQqjZeNdqGLZdxkaeM9tzNhoNex68FL4O20GiorAcdZeXsP1_5AyOAj3M</recordid><startdate>20030201</startdate><enddate>20030201</enddate><creator>BARTUONKOVA, Jirina</creator><creator>TESAR, Vladimir</creator><creator>SEDIVA, Anna</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20030201</creationdate><title>Diagnostic and pathogenetic role of antineutrophil cytoplasmic autoantibodies</title><author>BARTUONKOVA, Jirina ; TESAR, Vladimir ; SEDIVA, Anna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-fb82008e4286e095c765f51dc24904e5793f125c04f1b2a6902aad37ba6af0733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Aged</topic><topic>Animals</topic><topic>Antibodies, Antineutrophil Cytoplasmic - analysis</topic><topic>Antibodies, Antineutrophil Cytoplasmic - immunology</topic><topic>Antimicrobial Cationic Peptides</topic><topic>Antineutrophil cytoplasmic antibodies</topic><topic>Arthritis, Rheumatoid - immunology</topic><topic>Autoantigens - immunology</topic><topic>Autoimmune Diseases - chemically induced</topic><topic>Autoimmune Diseases - diagnosis</topic><topic>Autoimmune Diseases - genetics</topic><topic>Autoimmune Diseases - immunology</topic><topic>Biological and medical sciences</topic><topic>Blood Proteins - immunology</topic><topic>Cell Adhesion Molecules - physiology</topic><topic>Child</topic><topic>Children</topic><topic>Colitis, Ulcerative - immunology</topic><topic>Cystic Fibrosis - genetics</topic><topic>Cystic Fibrosis - immunology</topic><topic>Cytokines - physiology</topic><topic>Diagnostic association</topic><topic>Etiopathogenesis</topic><topic>General aspects</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Infection - complications</topic><topic>Medical sciences</topic><topic>Membrane Proteins</topic><topic>Mice</topic><topic>Middle Aged</topic><topic>Myeloblastin</topic><topic>Neutrophils - enzymology</topic><topic>Neutrophils - immunology</topic><topic>Neutrophils - pathology</topic><topic>Peroxidase - immunology</topic><topic>Respiratory Burst</topic><topic>Serine Endopeptidases - immunology</topic><topic>Silicosis - complications</topic><topic>Vasculitis - chemically induced</topic><topic>Vasculitis - diagnosis</topic><topic>Vasculitis - genetics</topic><topic>Vasculitis - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BARTUONKOVA, Jirina</creatorcontrib><creatorcontrib>TESAR, Vladimir</creatorcontrib><creatorcontrib>SEDIVA, Anna</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Clinical immunology (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BARTUONKOVA, Jirina</au><au>TESAR, Vladimir</au><au>SEDIVA, Anna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic and pathogenetic role of antineutrophil cytoplasmic autoantibodies</atitle><jtitle>Clinical immunology (Orlando, Fla.)</jtitle><addtitle>Clin Immunol</addtitle><date>2003-02-01</date><risdate>2003</risdate><volume>106</volume><issue>2</issue><spage>73</spage><epage>82</epage><pages>73-82</pages><issn>1521-6616</issn><eissn>1521-7035</eissn><coden>CLIIFY</coden><abstract>Anti-neutrophil cytoplasmic antibodies (ANCA) are mostly known as a useful diagnostic tool in patients with small-vessel vasculitides. With the accumulating knowledge of these autoantibodies, however, it becomes clear that the role of ANCA may not be only limited to a diagnosis of such disorders. The current review addresses, in addition to classical diagnostic associations, other diseases connected with ANCA positivity, both in adults and in children. The etiology of ANCA remains unknown, but still, the importance of both genetic and environmental factors is undoubted. The role of infection and chemicals in the etiology of ANCA-associated diseases is stressed in particular. A pathogenetic role of ANCA is suggested because of clinical observations based on the correlation of the vasculitis activity and the titer of ANCA. Many experiments show the effects of ANCA in various steps of an inflammatory process, particularly on leukocyte microbicidal activity and oxidative burst. 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| subjects | Adult Adults Aged Animals Antibodies, Antineutrophil Cytoplasmic - analysis Antibodies, Antineutrophil Cytoplasmic - immunology Antimicrobial Cationic Peptides Antineutrophil cytoplasmic antibodies Arthritis, Rheumatoid - immunology Autoantigens - immunology Autoimmune Diseases - chemically induced Autoimmune Diseases - diagnosis Autoimmune Diseases - genetics Autoimmune Diseases - immunology Biological and medical sciences Blood Proteins - immunology Cell Adhesion Molecules - physiology Child Children Colitis, Ulcerative - immunology Cystic Fibrosis - genetics Cystic Fibrosis - immunology Cytokines - physiology Diagnostic association Etiopathogenesis General aspects Humans Immunopathology Infection - complications Medical sciences Membrane Proteins Mice Middle Aged Myeloblastin Neutrophils - enzymology Neutrophils - immunology Neutrophils - pathology Peroxidase - immunology Respiratory Burst Serine Endopeptidases - immunology Silicosis - complications Vasculitis - chemically induced Vasculitis - diagnosis Vasculitis - genetics Vasculitis - immunology |
| title | Diagnostic and pathogenetic role of antineutrophil cytoplasmic autoantibodies |
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