Vitamin D‐Mediated Hypercalcemia in Lymphoma: Evidence for Hormone Production by Tumor‐Adjacent Macrophages

Nearly one‐half of all hypercalcemic patients with lymphoma present with inappropriately elevated circulating concentrations of the active vitamin D metabolite 1,25‐dihydroxyvitamin D (1,25(OH)2D3). However, the cellular source of the vitamin D hormone in lymphomas remains unclear. To address this,...

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Veröffentlicht in:	Journal of bone and mineral research 2003-03, Vol.18 (3), p.579-582
Hauptverfasser:	Hewison, Martin, Kantorovich, Vitaly, Liker, Harley R, Van Herle, Andre J, Cohan, Pejman, Zehnder, Daniel, Adams, John S
Format:	Artikel
Sprache:	eng
Schlagworte:	1α‐hydroxylase Aged Biological and medical sciences Hematologic and hematopoietic diseases Humans hypercalcemia Hypercalcemia - chemically induced Hypercalcemia - complications Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis lymphoma Lymphoma, B-Cell - complications Lymphoma, B-Cell - diagnosis Lymphoma, Large B-Cell, Diffuse - complications Lymphoma, Large B-Cell, Diffuse - diagnosis macrophage Male Medical sciences Tomography, Emission-Computed vitamin D Vitamin D - adverse effects
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