37-kDa Laminin Receptor Precursor Modulates Cytotoxic Necrotizing Factor 1–mediated RhoA Activation and Bacterial Uptake

Cytotoxic necrotizing factor 1 (CNF1) is a bacterial toxin known to activate Rho GTPases and induce host cell cytoskeleton rearrangements. The constitutive activation of Rho GTPases by CNF1 is shown to enhance bacterial uptake in epithelial cells and human brain microvascular endothelial cells. Howe...

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Veröffentlicht in:	The Journal of biological chemistry 2003-05, Vol.278 (19), p.16857-16862
Hauptverfasser:	Chung, Jin Woong, Hong, Suk Jin, Kim, Kee Jun, Goti, Daniel, Stins, Monique F., Shin, Sooan, Dawson, Valina L., Dawson, Ted M., Kim, Kwang Sik
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Toxins Cell Line Cytotoxins - physiology Endothelium, Vascular - microbiology Endothelium, Vascular - physiology Enzyme Activation Escherichia coli - physiology Escherichia coli Infections - etiology Escherichia coli Infections - metabolism Escherichia coli Proteins Oligonucleotides, Antisense Protein Binding Protein Precursors - physiology Receptors, Laminin - physiology rhoA GTP-Binding Protein - physiology Signal Transduction
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