Toll‐like receptor‐induced expression of epithelial cytokine receptors on haemopoietic progenitors is altered in allergic asthma

Summary Background Haemopoietic progenitor cells (HPC) migrate to sites of allergic inflammation where, upon stimulation with epithelial cytokines, they produce Th2 cytokines and differentiate into mature eosinophils and basophils. They also express Toll‐like receptors (TLR) involved in antimicrobia...

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Veröffentlicht in:	Clinical and experimental allergy 2017-07, Vol.47 (7), p.900-908
Hauptverfasser:	Tworek, D., Heroux, D., O'Byrne, S. N., Mitchell, P., O'Byrne, P. M., Denburg, J. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged allergen challenge Allergens Allergens - immunology Allergies Asthma Asthma - diagnosis Asthma - etiology Asthma - metabolism Asthma - therapy Basophils - immunology Basophils - metabolism Cell migration Cross-Over Studies Cytokine receptors Cytokines Cytokines - metabolism Dexamethasone epithelium Flow cytometry Gene Expression Regulation haemopoietic progenitor cells Hematopoietic Stem Cells - metabolism Hemopoiesis Humans Hypersensitivity Inflammation Inflammatory response Inhalation innate immunity Leukocytes (basophilic) Leukocytes (eosinophilic) Lymphocytes T Macrophages - immunology Macrophages - metabolism Middle Aged Neutrophils - immunology Neutrophils - metabolism Pathogens Peripheral blood Population studies Receptors, Cytokine - genetics Respiration Respiratory Function Tests Respiratory Mucosa - immunology Respiratory Mucosa - metabolism Respiratory Mucosa - pathology Stem cells Stimulation T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Thymic stromal lymphopoietin Thymus TLR2 protein TLR9 protein Toll-like receptors Toll-Like Receptors - metabolism TSLPR Young Adult
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