Species Difference in Sensitivity of Human and Mouse P2X7 Receptors to Inhibitory Effects of Divalent Metal Cations

P2X7 receptor (P2X7R), a purinergic receptor, is involved in pathophysiological events such as inflammation and cell death, and thus is an attractive target for therapeutic approaches. It is reported that divalent metal cations (DMCs) inhibit P2X7R activation and that there are species differences i...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biological & pharmaceutical bulletin 2017/03/01, Vol.40(3), pp.375-380
Hauptverfasser:	Fujiwara, Makiko, Ohbori, Kenshi, Ohishi, Akihiro, Nishida, Kentaro, Uozumi, Yoshinobu, Nagasawa, Kazuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzoxazoles - metabolism Calcium Calcium - pharmacology Calcium chloride Cations Cations, Divalent - pharmacology Cell activation Cell death Cell lines Copper Copper - pharmacology divalent metal cation HEK293 Cells Humans IC50 value Inhibitory Concentration 50 Magnesium Magnesium - pharmacology Magnesium chloride Metals Mice Nickel Nickel - pharmacology P2X7 receptor Quinolinium Compounds - metabolism Receptors, Purinergic P2X7 - genetics Receptors, Purinergic P2X7 - metabolism Sensitivity Species species difference Species Specificity Zinc Zinc - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!