Nicotinic alpha 7 Receptor Clusters on Hippocampal GABAergic Neurons: Regulation by Synaptic Activity and Neurotrophins

Nicotinic acetylcholine receptors containing the alpha7 gene product are expressed at substantial levels in the hippocampus. Because of their specific locations and their high relative calcium permeability, the receptors not only mediate cholinergic transmission in the hippocampus but also influence...

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Veröffentlicht in:	The Journal of neuroscience 2002-09, Vol.22 (18), p.7903-7912
Hauptverfasser:	Kawai, Hideki, Zago, Wagner, Berg, Darwin K
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha7 Nicotinic Acetylcholine Receptor Animals Cells, Cultured Excitatory Amino Acid Antagonists - pharmacology Fluorescent Dyes GABA Antagonists - pharmacology gamma-Aminobutyric Acid - metabolism Glutamate Decarboxylase - metabolism Hippocampus - cytology Hippocampus - drug effects Hippocampus - metabolism Image Processing, Computer-Assisted Microscopy, Fluorescence Nerve Growth Factors - metabolism Neurons - drug effects Neurons - metabolism Neurons - ultrastructure Presynaptic Terminals - drug effects Presynaptic Terminals - metabolism Pseudopodia - metabolism Rats Rats, Sprague-Dawley Receptor Aggregation - drug effects Receptor Aggregation - physiology Receptors, Nicotinic - metabolism Synapses - metabolism Synaptic Transmission - drug effects Synaptic Transmission - physiology Tetrodotoxin - pharmacology
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