Variation in Inter-Animal Susceptibility to Noise Damage Is Associated with alpha 9 Acetylcholine Receptor Subunit Expression Level

Large intersubject variabilities in acoustic injury are known to occur in both humans and animals; however, the mechanisms underlying such differences are poorly understood. The olivocochlear efferent system has been hypothesized to play a significant role in protecting the cochlea from noise overex...

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Veröffentlicht in:	The Journal of neuroscience 2002-05, Vol.22 (10), p.4241-4247
Hauptverfasser:	Luebke, Anne E, Foster, Paul K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic Stimulation Adaptation, Physiological Animals Blotting, Western Cochlea - cytology Cochlea - metabolism Disease Susceptibility - metabolism Efferent Pathways - physiology Genetic Variation Guinea Pigs Hair Cells, Auditory, Inner - cytology Hair Cells, Auditory, Inner - metabolism Hair Cells, Auditory, Outer - cytology Hair Cells, Auditory, Outer - metabolism Hearing Loss, Noise-Induced - etiology Hearing Loss, Noise-Induced - metabolism Immunohistochemistry Noise - adverse effects Otoacoustic Emissions, Spontaneous Predictive Value of Tests Protein Subunits Receptors, Nicotinic - metabolism Reflex, Acoustic - physiology
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