The Role of NR2B-CREB-miR212/132-CRTC1-CREB Signal Network in Pain Regulation In Vitro and In Vivo

Chronic pain is a debilitating threat to human health, and its molecular mechanism remains undefined. Previous studies have illustrated a key role of cAMP response element-binding protein (CREB) in pain regulation; CREB-regulated transcription coactivator 1 (CRTC1) and microRNA212/132 (miR212/132) a...

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Veröffentlicht in:	Anesthesia and analgesia 2017-06, Vol.124 (6), p.2045-2053
Hauptverfasser:	Xia, Tianjiao, Chu, Shuaishuai, Cui, Yin, Xu, Fangxia, Liu, Yue, Song, Jia, Qian, Yue, Shao, Xueming, Li, Xiuxiu, Gu, Xiaoping, Ma, Zhengliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Chronic Pain - genetics Chronic Pain - metabolism Chronic Pain - physiopathology Cyclic AMP Response Element-Binding Protein - genetics Cyclic AMP Response Element-Binding Protein - metabolism Disease Models, Animal Gene Expression Regulation Hyperalgesia - genetics Hyperalgesia - metabolism Hyperalgesia - physiopathology Male Mice, Inbred C57BL MicroRNAs - genetics MicroRNAs - metabolism Neurons - metabolism Pain Threshold Primary Cell Culture Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction Spinal Cord - embryology Spinal Cord - metabolism Spinal Cord - physiopathology Transcription Factors - genetics Transcription Factors - metabolism
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