Adjunctive therapy with statins reduces residual albuminuria/proteinuria and provides further renoprotection by downregulating the angiotensin II-AT1 pathway in hypertensive nephropathy

Blockade of the renin-angiotensin II (Ang II) system by AT1 blockers (ARBs) and angiotensin-converting enzyme inhibitors retards the progression of chronic kidney disease (CKD) by reducing albuminuria/proteinuria. However, many patients with CKD suffer from residual albuminuria/proteinuria, which is...

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Veröffentlicht in:	Journal of hypertension 2017-07, Vol.35 (7), p.1442-1456
Hauptverfasser:	Zhang, Zhi, Li, Ziqiang, Cao, Kaijin, Fang, Dailong, Wang, Fazhan, Bi, Gang, Yang, Jian, He, Yingju, Wu, Jinhui, Wei, Yuquan, Song, Xiangrong
Format:	Artikel
Sprache:	eng
Schlagworte:	Albuminuria - drug therapy Albuminuria - metabolism Angiotensin II - metabolism Angiotensin II Type 1 Receptor Blockers - pharmacology Angiotensin II Type 1 Receptor Blockers - therapeutic use Angiotensin-Converting Enzyme Inhibitors - pharmacology Angiotensin-Converting Enzyme Inhibitors - therapeutic use Animals Benzimidazoles - pharmacology Benzimidazoles - therapeutic use Benzoates - pharmacology Benzoates - therapeutic use Down-Regulation - drug effects Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Hypertension, Renal - drug therapy Hypertension, Renal - metabolism Kidney - drug effects Kidney - metabolism Male Nephritis - drug therapy Nephritis - metabolism NF-kappa B - metabolism Proteinuria - drug therapy Rats Rats, Inbred SHR Receptor, Angiotensin, Type 1 - metabolism Renin-Angiotensin System - drug effects Signal Transduction - drug effects Transforming Growth Factor beta - metabolism
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