Consumption of nuts and seeds and telomere length in 5,582 men and women of the National Health and Nutrition Examination Survey (NHANES)
Objectives Consumption of nuts and seeds is associated favorably with all-cause mortality. Nuts and seeds could reduce disease and prolong life by influencing telomeres. Telomere length is a good indicator of the senescence of cells. The purpose of the present study was to determine the relationship...
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| Veröffentlicht in: | The Journal of nutrition, health & aging health & aging, 2017-03, Vol.21 (3), p.233-240 |
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| description | Objectives
Consumption of nuts and seeds is associated favorably with all-cause mortality. Nuts and seeds could reduce disease and prolong life by influencing telomeres. Telomere length is a good indicator of the senescence of cells. The purpose of the present study was to determine the relationship between nuts and seeds intake and leukocyte telomere length, a biomarker of biologic aging.
Design
Cross-sectional.
Setting and Participants
A total of 5,582 randomly selected men and women from the National Health and Nutrition Examination Survey (NHANES), 1999-2002, were studied.
Measurements
DNA was obtained via blood samples. Telomere length was assessed using the quantitative polymerase chain reaction method. A validated, multi-pass, 24-h recall dietary assessment, administered by NHANES, was employed to quantify consumption of nuts and seeds.
Results
Nuts and seeds intake was positively and linearly associated with telomere length. For each 1-percent of total energy derived from nuts and seeds, telomere length was 5 base pairs longer (F=8.6, P=0.0065). Given the age-related rate of telomere shortening was 15.4 base pairs per year (F=581.1, P |
| doi_str_mv | 10.1007/s12603-017-0876-5 |
| format | Article |
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Consumption of nuts and seeds is associated favorably with all-cause mortality. Nuts and seeds could reduce disease and prolong life by influencing telomeres. Telomere length is a good indicator of the senescence of cells. The purpose of the present study was to determine the relationship between nuts and seeds intake and leukocyte telomere length, a biomarker of biologic aging.
Design
Cross-sectional.
Setting and Participants
A total of 5,582 randomly selected men and women from the National Health and Nutrition Examination Survey (NHANES), 1999-2002, were studied.
Measurements
DNA was obtained via blood samples. Telomere length was assessed using the quantitative polymerase chain reaction method. A validated, multi-pass, 24-h recall dietary assessment, administered by NHANES, was employed to quantify consumption of nuts and seeds.
Results
Nuts and seeds intake was positively and linearly associated with telomere length. For each 1-percent of total energy derived from nuts and seeds, telomere length was 5 base pairs longer (F=8.6, P=0.0065). Given the age-related rate of telomere shortening was 15.4 base pairs per year (F=581.1, P<0.0001), adults of the same age had more than 1.5 years of reduced cell aging if they consumed 5% of their total energy from nuts and seeds.
Conclusions
Consumption of nuts and seeds accounts for meaningful decreases in biologic aging and cell senescence. The findings reinforce the recommendations of the 2015-2020 Dietary Guidelines for Americans, which encourage the consumption of nuts and seeds as part of a healthy diet.</description><identifier>ISSN: 1279-7707</identifier><identifier>EISSN: 1760-4788</identifier><identifier>DOI: 10.1007/s12603-017-0876-5</identifier><identifier>PMID: 28244560</identifier><language>eng</language><publisher>Paris: Springer Paris</publisher><subject>Adult ; Aging ; Aging - physiology ; Biomarkers ; Biomarkers - blood ; Cardiovascular disease ; Cellular Senescence - physiology ; Chronic illnesses ; Cross-Sectional Studies ; Diet ; Dietary guidelines ; Disease control ; Disease prevention ; Female ; Genetic testing ; Geriatrics/Gerontology ; Humans ; Leukocytes ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Mortality ; Neurosciences ; Nutrition ; Nutrition Policy ; Nutrition research ; Nutrition Surveys - methods ; Nuts ; Primary Care Medicine ; Quality of Life Research ; Real-Time Polymerase Chain Reaction ; Seeds ; Senescence ; Telomerase ; Telomere - physiology ; Telomere Shortening - physiology ; Womens health ; Yeast</subject><ispartof>The Journal of nutrition, health & aging, 2017-03, Vol.21 (3), p.233-240</ispartof><rights>Serdi and Springer-Verlag France 2017</rights><rights>The journal of nutrition, health & aging is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-eeb50712bd11864f6d2ffa83923cc78b08c1109e1ce93a5cdbe9f522ae281ed43</citedby><cites>FETCH-LOGICAL-c372t-eeb50712bd11864f6d2ffa83923cc78b08c1109e1ce93a5cdbe9f522ae281ed43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12603-017-0876-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12603-017-0876-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28244560$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tucker, Larry A.</creatorcontrib><title>Consumption of nuts and seeds and telomere length in 5,582 men and women of the National Health and Nutrition Examination Survey (NHANES)</title><title>The Journal of nutrition, health & aging</title><addtitle>J Nutr Health Aging</addtitle><addtitle>J Nutr Health Aging</addtitle><description>Objectives
Consumption of nuts and seeds is associated favorably with all-cause mortality. Nuts and seeds could reduce disease and prolong life by influencing telomeres. Telomere length is a good indicator of the senescence of cells. The purpose of the present study was to determine the relationship between nuts and seeds intake and leukocyte telomere length, a biomarker of biologic aging.
Design
Cross-sectional.
Setting and Participants
A total of 5,582 randomly selected men and women from the National Health and Nutrition Examination Survey (NHANES), 1999-2002, were studied.
Measurements
DNA was obtained via blood samples. Telomere length was assessed using the quantitative polymerase chain reaction method. A validated, multi-pass, 24-h recall dietary assessment, administered by NHANES, was employed to quantify consumption of nuts and seeds.
Results
Nuts and seeds intake was positively and linearly associated with telomere length. For each 1-percent of total energy derived from nuts and seeds, telomere length was 5 base pairs longer (F=8.6, P=0.0065). Given the age-related rate of telomere shortening was 15.4 base pairs per year (F=581.1, P<0.0001), adults of the same age had more than 1.5 years of reduced cell aging if they consumed 5% of their total energy from nuts and seeds.
Conclusions
Consumption of nuts and seeds accounts for meaningful decreases in biologic aging and cell senescence. The findings reinforce the recommendations of the 2015-2020 Dietary Guidelines for Americans, which encourage the consumption of nuts and seeds as part of a healthy diet.</description><subject>Adult</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Cardiovascular disease</subject><subject>Cellular Senescence - physiology</subject><subject>Chronic illnesses</subject><subject>Cross-Sectional Studies</subject><subject>Diet</subject><subject>Dietary guidelines</subject><subject>Disease control</subject><subject>Disease prevention</subject><subject>Female</subject><subject>Genetic testing</subject><subject>Geriatrics/Gerontology</subject><subject>Humans</subject><subject>Leukocytes</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Neurosciences</subject><subject>Nutrition</subject><subject>Nutrition Policy</subject><subject>Nutrition research</subject><subject>Nutrition Surveys - methods</subject><subject>Nuts</subject><subject>Primary Care Medicine</subject><subject>Quality of Life Research</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Seeds</subject><subject>Senescence</subject><subject>Telomerase</subject><subject>Telomere - physiology</subject><subject>Telomere Shortening - physiology</subject><subject>Womens health</subject><subject>Yeast</subject><issn>1279-7707</issn><issn>1760-4788</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc1q3DAUhUVJaX7aB8gmCLKZQNzox7Lk5TBMM4UwXSRdC9m-zniwpYlkJ5lH6FtXHqelBLq6B-53zuVyEDqn5CslRN4EyjLCE0JlQpTMEvEBnVCZkSSVSh1FzWSeSEnkMToNYUtIKnKVfULHTLE0FRk5Qb8Wzoah2_WNs9jV2A59wMZWOABUk-qhdR14wC3Yx36DG4vFtVAMd2APwIsbVTT3G8BrM0aZFq_AtJEegfXQ--ZwYflqusYeEHw_-GfY49l6NV8v768-o4-1aQN8eZtn6Oe35cNildz9uP2-mN8lJZesTwAKQSRlRUWpytI6q1hdG8VzxstSqoKoklKSAy0h50aUVQF5LRgzwBSFKuVnaDbl7rx7GiD0umtCCW1rLLghaKokU0pyziJ6-Q7dusHH5w4UVyKXdAykE1V6F4KHWu980xm_15TosSc99aRjT3rsSYvouXhLHooOqr-OP8VEgE1AiCv7CP6f0_9N_Q2G5Jzt</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Tucker, Larry A.</creator><general>Springer Paris</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20170301</creationdate><title>Consumption of nuts and seeds and telomere length in 5,582 men and women of the National Health and Nutrition Examination Survey (NHANES)</title><author>Tucker, Larry A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-eeb50712bd11864f6d2ffa83923cc78b08c1109e1ce93a5cdbe9f522ae281ed43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aging</topic><topic>Aging - physiology</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Cardiovascular disease</topic><topic>Cellular Senescence - physiology</topic><topic>Chronic illnesses</topic><topic>Cross-Sectional Studies</topic><topic>Diet</topic><topic>Dietary guidelines</topic><topic>Disease control</topic><topic>Disease prevention</topic><topic>Female</topic><topic>Genetic testing</topic><topic>Geriatrics/Gerontology</topic><topic>Humans</topic><topic>Leukocytes</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Neurosciences</topic><topic>Nutrition</topic><topic>Nutrition Policy</topic><topic>Nutrition research</topic><topic>Nutrition Surveys - methods</topic><topic>Nuts</topic><topic>Primary Care Medicine</topic><topic>Quality of Life Research</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Seeds</topic><topic>Senescence</topic><topic>Telomerase</topic><topic>Telomere - physiology</topic><topic>Telomere Shortening - physiology</topic><topic>Womens health</topic><topic>Yeast</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tucker, Larry A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition, health & aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tucker, Larry A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Consumption of nuts and seeds and telomere length in 5,582 men and women of the National Health and Nutrition Examination Survey (NHANES)</atitle><jtitle>The Journal of nutrition, health & aging</jtitle><stitle>J Nutr Health Aging</stitle><addtitle>J Nutr Health Aging</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>21</volume><issue>3</issue><spage>233</spage><epage>240</epage><pages>233-240</pages><issn>1279-7707</issn><eissn>1760-4788</eissn><abstract>Objectives
Consumption of nuts and seeds is associated favorably with all-cause mortality. Nuts and seeds could reduce disease and prolong life by influencing telomeres. Telomere length is a good indicator of the senescence of cells. The purpose of the present study was to determine the relationship between nuts and seeds intake and leukocyte telomere length, a biomarker of biologic aging.
Design
Cross-sectional.
Setting and Participants
A total of 5,582 randomly selected men and women from the National Health and Nutrition Examination Survey (NHANES), 1999-2002, were studied.
Measurements
DNA was obtained via blood samples. Telomere length was assessed using the quantitative polymerase chain reaction method. A validated, multi-pass, 24-h recall dietary assessment, administered by NHANES, was employed to quantify consumption of nuts and seeds.
Results
Nuts and seeds intake was positively and linearly associated with telomere length. For each 1-percent of total energy derived from nuts and seeds, telomere length was 5 base pairs longer (F=8.6, P=0.0065). Given the age-related rate of telomere shortening was 15.4 base pairs per year (F=581.1, P<0.0001), adults of the same age had more than 1.5 years of reduced cell aging if they consumed 5% of their total energy from nuts and seeds.
Conclusions
Consumption of nuts and seeds accounts for meaningful decreases in biologic aging and cell senescence. The findings reinforce the recommendations of the 2015-2020 Dietary Guidelines for Americans, which encourage the consumption of nuts and seeds as part of a healthy diet.</abstract><cop>Paris</cop><pub>Springer Paris</pub><pmid>28244560</pmid><doi>10.1007/s12603-017-0876-5</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1279-7707 |
| ispartof | The Journal of nutrition, health & aging, 2017-03, Vol.21 (3), p.233-240 |
| issn | 1279-7707 1760-4788 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1872887332 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; Alma/SFX Local Collection |
| subjects | Adult Aging Aging - physiology Biomarkers Biomarkers - blood Cardiovascular disease Cellular Senescence - physiology Chronic illnesses Cross-Sectional Studies Diet Dietary guidelines Disease control Disease prevention Female Genetic testing Geriatrics/Gerontology Humans Leukocytes Male Medicine Medicine & Public Health Middle Aged Mortality Neurosciences Nutrition Nutrition Policy Nutrition research Nutrition Surveys - methods Nuts Primary Care Medicine Quality of Life Research Real-Time Polymerase Chain Reaction Seeds Senescence Telomerase Telomere - physiology Telomere Shortening - physiology Womens health Yeast |
| title | Consumption of nuts and seeds and telomere length in 5,582 men and women of the National Health and Nutrition Examination Survey (NHANES) |
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