The Role of MicroRNAs on Adipogenesis, Chronic Low Grade Inflammation and Insulin Resistance in Obesity
Abstract The objective of this review is to convey updated information on the role of microRNAs in adipogenesis, chronic low grade inflammation and insulin resistance in obesity. Obesity is a chronic disease characterized by the presence of metabolic disorders, e.g., low-grade chronic inflammation,...
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| Veröffentlicht in: | Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2017-03, Vol.35, p.28-35 |
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| creator | Cruz, Kyria Jayanne Clímaco, MSc Oliveira, Ana Raquel Soares de, MSc Morais, Jennifer Beatriz Silva Severo, Juliana Soares Marreiro, Dilina do Nascimento, Dr |
| description | Abstract The objective of this review is to convey updated information on the role of microRNAs in adipogenesis, chronic low grade inflammation and insulin resistance in obesity. Obesity is a chronic disease characterized by the presence of metabolic disorders, e.g., low-grade chronic inflammation, which contributes to the manifestation of insulin resistance. Diverse molecular mechanisms have been implicated in the development of these disorders, and microRNAs stand out as a contributing factor. They are a class of noncoding RNAs that regulate the expression of genes by inducing cleavage of mRNAs or via inhibition of protein translation. It is important to point out that obese individuals show alterations in the expression of microRNAs favoring manifestation of the metabolic disorders present in these patients, and these alterations may be reversed by the loss of weight. Therefore, microRNAs may be regarded as potential biomarkers of obesity-related disorders. Further studies on this topic may advance the understanding of the molecular basis of obesity, including the participation of microRNAs in the pathogenesis of this disease. |
| doi_str_mv | 10.1016/j.nut.2016.10.003 |
| format | Article |
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Obesity is a chronic disease characterized by the presence of metabolic disorders, e.g., low-grade chronic inflammation, which contributes to the manifestation of insulin resistance. Diverse molecular mechanisms have been implicated in the development of these disorders, and microRNAs stand out as a contributing factor. They are a class of noncoding RNAs that regulate the expression of genes by inducing cleavage of mRNAs or via inhibition of protein translation. It is important to point out that obese individuals show alterations in the expression of microRNAs favoring manifestation of the metabolic disorders present in these patients, and these alterations may be reversed by the loss of weight. Therefore, microRNAs may be regarded as potential biomarkers of obesity-related disorders. Further studies on this topic may advance the understanding of the molecular basis of obesity, including the participation of microRNAs in the pathogenesis of this disease.</description><identifier>ISSN: 0899-9007</identifier><identifier>EISSN: 1873-1244</identifier><identifier>DOI: 10.1016/j.nut.2016.10.003</identifier><identifier>PMID: 28241987</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adipocytes ; Adipogenesis ; Adipogenesis - genetics ; Cell Differentiation ; Cell Proliferation ; Chronic inflammation ; Gastroenterology and Hepatology ; Genetic Markers ; Humans ; Inflammation - genetics ; Insulin resistance ; Insulin Resistance - genetics ; Kinases ; Metabolic Diseases - genetics ; Metabolic disorders ; microRNAs ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Obesity ; Obesity - genetics ; Studies</subject><ispartof>Nutrition (Burbank, Los Angeles County, Calif.), 2017-03, Vol.35, p.28-35</ispartof><rights>Elsevier Inc.</rights><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Mar 01, 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-a5766f73b9bc63be54f0c35bbc27298fed38ccd77276312ba907a8915223108c3</citedby><cites>FETCH-LOGICAL-c502t-a5766f73b9bc63be54f0c35bbc27298fed38ccd77276312ba907a8915223108c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0899900716302246$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28241987$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cruz, Kyria Jayanne Clímaco, MSc</creatorcontrib><creatorcontrib>Oliveira, Ana Raquel Soares de, MSc</creatorcontrib><creatorcontrib>Morais, Jennifer Beatriz Silva</creatorcontrib><creatorcontrib>Severo, Juliana Soares</creatorcontrib><creatorcontrib>Marreiro, Dilina do Nascimento, Dr</creatorcontrib><title>The Role of MicroRNAs on Adipogenesis, Chronic Low Grade Inflammation and Insulin Resistance in Obesity</title><title>Nutrition (Burbank, Los Angeles County, Calif.)</title><addtitle>Nutrition</addtitle><description>Abstract The objective of this review is to convey updated information on the role of microRNAs in adipogenesis, chronic low grade inflammation and insulin resistance in obesity. Obesity is a chronic disease characterized by the presence of metabolic disorders, e.g., low-grade chronic inflammation, which contributes to the manifestation of insulin resistance. Diverse molecular mechanisms have been implicated in the development of these disorders, and microRNAs stand out as a contributing factor. They are a class of noncoding RNAs that regulate the expression of genes by inducing cleavage of mRNAs or via inhibition of protein translation. It is important to point out that obese individuals show alterations in the expression of microRNAs favoring manifestation of the metabolic disorders present in these patients, and these alterations may be reversed by the loss of weight. Therefore, microRNAs may be regarded as potential biomarkers of obesity-related disorders. Further studies on this topic may advance the understanding of the molecular basis of obesity, including the participation of microRNAs in the pathogenesis of this disease.</description><subject>Adipocytes</subject><subject>Adipogenesis</subject><subject>Adipogenesis - genetics</subject><subject>Cell Differentiation</subject><subject>Cell Proliferation</subject><subject>Chronic inflammation</subject><subject>Gastroenterology and Hepatology</subject><subject>Genetic Markers</subject><subject>Humans</subject><subject>Inflammation - genetics</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - genetics</subject><subject>Kinases</subject><subject>Metabolic Diseases - genetics</subject><subject>Metabolic disorders</subject><subject>microRNAs</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Obesity</subject><subject>Obesity - genetics</subject><subject>Studies</subject><issn>0899-9007</issn><issn>1873-1244</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kl-L1DAUxYMo7uzoB_BFAr74sB3zp20SBGEYdF0YXRjX55Cmt7sZ22RMWmW-vamzKuyDEEju5XcuyTlB6AUlK0po_Wa_8tO4YvmY6xUh_BFaUCl4QVlZPkYLIpUqFCHiDJ2ntCeEUFWrp-iMSVZSJcUC3d7cAd6FHnDo8CdnY9h9XiccPF637hBuwUNy6QJv7mLwzuJt-Ikvo2kBX_muN8NgRpdh49vcSFPvPN7NitF4CzhX100ux-Mz9KQzfYLn9_sSff3w_mbzsdheX15t1tvCVoSNhalEXXeCN6qxNW-gKjtiedU0lgmmZActl9a2QjBRc8oao4gwUtGKMU6JtHyJXp_mHmL4PkEa9eCShb43HsKUdLaHSSE4kRl99QDdhyn6fLvfVFUrntcS0ROVrUkpQqcP0Q0mHjUlek5B73VOQc8pzK2cQta8vJ88NQO0fxV_bM_A2xMA2YofDqJO1kF2rHUR7Kjb4P47_t0Dtc2-O2v6b3CE9O8VOjFN9Jf5G8y_gNacMFbW_BdinKsH</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Cruz, Kyria Jayanne Clímaco, MSc</creator><creator>Oliveira, Ana Raquel Soares de, MSc</creator><creator>Morais, Jennifer Beatriz Silva</creator><creator>Severo, Juliana Soares</creator><creator>Marreiro, Dilina do Nascimento, Dr</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20170301</creationdate><title>The Role of MicroRNAs on Adipogenesis, Chronic Low Grade Inflammation and Insulin Resistance in Obesity</title><author>Cruz, Kyria Jayanne Clímaco, MSc ; Oliveira, Ana Raquel Soares de, MSc ; Morais, Jennifer Beatriz Silva ; Severo, Juliana Soares ; Marreiro, Dilina do Nascimento, Dr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-a5766f73b9bc63be54f0c35bbc27298fed38ccd77276312ba907a8915223108c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adipocytes</topic><topic>Adipogenesis</topic><topic>Adipogenesis - genetics</topic><topic>Cell Differentiation</topic><topic>Cell Proliferation</topic><topic>Chronic inflammation</topic><topic>Gastroenterology and Hepatology</topic><topic>Genetic Markers</topic><topic>Humans</topic><topic>Inflammation - genetics</topic><topic>Insulin resistance</topic><topic>Insulin Resistance - genetics</topic><topic>Kinases</topic><topic>Metabolic Diseases - genetics</topic><topic>Metabolic disorders</topic><topic>microRNAs</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>Obesity</topic><topic>Obesity - genetics</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cruz, Kyria Jayanne Clímaco, MSc</creatorcontrib><creatorcontrib>Oliveira, Ana Raquel Soares de, MSc</creatorcontrib><creatorcontrib>Morais, Jennifer Beatriz Silva</creatorcontrib><creatorcontrib>Severo, Juliana Soares</creatorcontrib><creatorcontrib>Marreiro, Dilina do Nascimento, Dr</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cruz, Kyria Jayanne Clímaco, MSc</au><au>Oliveira, Ana Raquel Soares de, MSc</au><au>Morais, Jennifer Beatriz Silva</au><au>Severo, Juliana Soares</au><au>Marreiro, Dilina do Nascimento, Dr</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of MicroRNAs on Adipogenesis, Chronic Low Grade Inflammation and Insulin Resistance in Obesity</atitle><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle><addtitle>Nutrition</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>35</volume><spage>28</spage><epage>35</epage><pages>28-35</pages><issn>0899-9007</issn><eissn>1873-1244</eissn><abstract>Abstract The objective of this review is to convey updated information on the role of microRNAs in adipogenesis, chronic low grade inflammation and insulin resistance in obesity. Obesity is a chronic disease characterized by the presence of metabolic disorders, e.g., low-grade chronic inflammation, which contributes to the manifestation of insulin resistance. Diverse molecular mechanisms have been implicated in the development of these disorders, and microRNAs stand out as a contributing factor. They are a class of noncoding RNAs that regulate the expression of genes by inducing cleavage of mRNAs or via inhibition of protein translation. It is important to point out that obese individuals show alterations in the expression of microRNAs favoring manifestation of the metabolic disorders present in these patients, and these alterations may be reversed by the loss of weight. Therefore, microRNAs may be regarded as potential biomarkers of obesity-related disorders. Further studies on this topic may advance the understanding of the molecular basis of obesity, including the participation of microRNAs in the pathogenesis of this disease.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28241987</pmid><doi>10.1016/j.nut.2016.10.003</doi><tpages>8</tpages></addata></record> |
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| ispartof | Nutrition (Burbank, Los Angeles County, Calif.), 2017-03, Vol.35, p.28-35 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adipocytes Adipogenesis Adipogenesis - genetics Cell Differentiation Cell Proliferation Chronic inflammation Gastroenterology and Hepatology Genetic Markers Humans Inflammation - genetics Insulin resistance Insulin Resistance - genetics Kinases Metabolic Diseases - genetics Metabolic disorders microRNAs MicroRNAs - genetics MicroRNAs - metabolism Obesity Obesity - genetics Studies |
| title | The Role of MicroRNAs on Adipogenesis, Chronic Low Grade Inflammation and Insulin Resistance in Obesity |
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