Quantifying Possible Routes for SpnF-Catalyzed Formal Diels–Alder Cycloaddition

The Diels–Alder reaction is a cornerstone of modern organic synthesis. Despite this, it remains essentially inaccessible to biosynthetic approaches. Only a few natural enzymes catalyze even a formal [4 + 2] cycloaddition, and it remains uncertain if any of them proceed via the Diels–Alder mechanism....

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Veröffentlicht in:	Journal of the American Chemical Society 2017-03, Vol.139 (11), p.3942-3945
Hauptverfasser:	Medvedev, Michael G, Zeifman, Alexey A, Novikov, Fedor N, Bushmarinov, Ivan S, Stroganov, Oleg V, Titov, Ilya Yu, Chilov, Ghermes G, Svitanko, Igor V
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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