Juvenile xanthogranuloma with lichenoid appearance
Juvenile xanthogranulomas are benign histiocytic cell tumors that develop mainly in infancy and early childhood and then spontaneously regress. We report a 2‐year‐old boy who presented with generalized eruption of a mixture of micronodular and macronodular juvenile xanthogranuloma with a large numbe...
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| Veröffentlicht in: | Journal of dermatology 2012-05, Vol.39 (5), p.462-465 |
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| creator | YONEDA, Kozo DEMITSU, Toshio KUBOTA, Yasuo |
| description | Juvenile xanthogranulomas are benign histiocytic cell tumors that develop mainly in infancy and early childhood and then spontaneously regress. We report a 2‐year‐old boy who presented with generalized eruption of a mixture of micronodular and macronodular juvenile xanthogranuloma with a large number of widely distributed lichenoid papules. Light microscopic and immunocytochemical analyses of the lesion were consistent with juvenile xanthogranuloma. Abdominal ultrasonography did not detect any visceral lesions, and brain magnetic resonance imaging did not detect any mass lesions. We decided to observe the course without treatment in this case because there are no internal masses of juvenile xanthogranuloma. Regular follow up has therefore been scheduled. To our knowledge, this is the third report of a case demonstrating juvenile xanthogranuloma with lichenoid appearance. Future analyses of various cytokines such as granulocyte‐macrophage colony‐stimulating factor and/or tumor necrosis factor‐α in juvenile xanthogranuloma lesions should be of great help in elucidating the pathogenesis of this disease. |
| doi_str_mv | 10.1111/j.1346-8138.2011.01394.x |
| format | Article |
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We report a 2‐year‐old boy who presented with generalized eruption of a mixture of micronodular and macronodular juvenile xanthogranuloma with a large number of widely distributed lichenoid papules. Light microscopic and immunocytochemical analyses of the lesion were consistent with juvenile xanthogranuloma. Abdominal ultrasonography did not detect any visceral lesions, and brain magnetic resonance imaging did not detect any mass lesions. We decided to observe the course without treatment in this case because there are no internal masses of juvenile xanthogranuloma. Regular follow up has therefore been scheduled. To our knowledge, this is the third report of a case demonstrating juvenile xanthogranuloma with lichenoid appearance. 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We report a 2‐year‐old boy who presented with generalized eruption of a mixture of micronodular and macronodular juvenile xanthogranuloma with a large number of widely distributed lichenoid papules. Light microscopic and immunocytochemical analyses of the lesion were consistent with juvenile xanthogranuloma. Abdominal ultrasonography did not detect any visceral lesions, and brain magnetic resonance imaging did not detect any mass lesions. We decided to observe the course without treatment in this case because there are no internal masses of juvenile xanthogranuloma. Regular follow up has therefore been scheduled. To our knowledge, this is the third report of a case demonstrating juvenile xanthogranuloma with lichenoid appearance. Future analyses of various cytokines such as granulocyte‐macrophage colony‐stimulating factor and/or tumor necrosis factor‐α in juvenile xanthogranuloma lesions should be of great help in elucidating the pathogenesis of this disease.</description><subject>ALK</subject><subject>Benign</subject><subject>Case reports</subject><subject>CD68</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Cytokines</subject><subject>Eruptions</subject><subject>Granulocyte-macrophage colony-stimulating factor</subject><subject>histiocytosis</subject><subject>Humans</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Neuroimaging</subject><subject>Nodules</subject><subject>Remission, Spontaneous</subject><subject>Touton giant cell</subject><subject>Tumor necrosis factor- alpha</subject><subject>Ultrasonography</subject><subject>xanthogranuloma</subject><subject>Xanthogranuloma, Juvenile - diagnosis</subject><subject>Xanthogranuloma, Juvenile - etiology</subject><subject>Xanthogranuloma, Juvenile - pathology</subject><issn>0385-2407</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkbtOwzAUhi0EglJ4BRSJhSXh-Bp7YEDcUSUWmC3bcWiq3EgaaN8ehxYGFvBiS-c7_znWh1CEIcHhnC8STJmIJaYyIYBxApgqlqx20OSnsIsmQCWPCYP0AB32_QKAKI5hHx0QrCQoBRNEHod3Xxelj1amXs6b187UQ9lUJvoolvOoLNzc102RRaZtvQlF54_QXm7K3h9v7yl6ub15vrqPZ093D1eXs9hxLFgswYIBrJyimcsp48bkDtsUDDNCZtJSbgkhuclyajNimXFUccKJtUxwltIpOtvktl3zNvh-qauid74sTe2boddYpkQyRrH6GwWcKq5YKv6BAjAQAOMCp7_QRTN0dfhzmC2EYIIQHii5oVzX9H3nc912RWW6dYjSoy290KMUPUrRoy39ZUuvQuvJdsBgK5_9NH7rCcDFBvgIhtb_DtaP1zfji34CPIOgoQ</recordid><startdate>201205</startdate><enddate>201205</enddate><creator>YONEDA, Kozo</creator><creator>DEMITSU, Toshio</creator><creator>KUBOTA, Yasuo</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201205</creationdate><title>Juvenile xanthogranuloma with lichenoid appearance</title><author>YONEDA, Kozo ; DEMITSU, Toshio ; KUBOTA, Yasuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5164-80b0a019c93dcf345aafc1b70a4a68d8b35b222fadf3bd2b4ac395252bb465473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>ALK</topic><topic>Benign</topic><topic>Case reports</topic><topic>CD68</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Cytokines</topic><topic>Eruptions</topic><topic>Granulocyte-macrophage colony-stimulating factor</topic><topic>histiocytosis</topic><topic>Humans</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Neuroimaging</topic><topic>Nodules</topic><topic>Remission, Spontaneous</topic><topic>Touton giant cell</topic><topic>Tumor necrosis factor- alpha</topic><topic>Ultrasonography</topic><topic>xanthogranuloma</topic><topic>Xanthogranuloma, Juvenile - diagnosis</topic><topic>Xanthogranuloma, Juvenile - etiology</topic><topic>Xanthogranuloma, Juvenile - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YONEDA, Kozo</creatorcontrib><creatorcontrib>DEMITSU, Toshio</creatorcontrib><creatorcontrib>KUBOTA, Yasuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YONEDA, Kozo</au><au>DEMITSU, Toshio</au><au>KUBOTA, Yasuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Juvenile xanthogranuloma with lichenoid appearance</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>2012-05</date><risdate>2012</risdate><volume>39</volume><issue>5</issue><spage>462</spage><epage>465</epage><pages>462-465</pages><issn>0385-2407</issn><eissn>1346-8138</eissn><abstract>Juvenile xanthogranulomas are benign histiocytic cell tumors that develop mainly in infancy and early childhood and then spontaneously regress. We report a 2‐year‐old boy who presented with generalized eruption of a mixture of micronodular and macronodular juvenile xanthogranuloma with a large number of widely distributed lichenoid papules. Light microscopic and immunocytochemical analyses of the lesion were consistent with juvenile xanthogranuloma. Abdominal ultrasonography did not detect any visceral lesions, and brain magnetic resonance imaging did not detect any mass lesions. We decided to observe the course without treatment in this case because there are no internal masses of juvenile xanthogranuloma. Regular follow up has therefore been scheduled. To our knowledge, this is the third report of a case demonstrating juvenile xanthogranuloma with lichenoid appearance. Future analyses of various cytokines such as granulocyte‐macrophage colony‐stimulating factor and/or tumor necrosis factor‐α in juvenile xanthogranuloma lesions should be of great help in elucidating the pathogenesis of this disease.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21980990</pmid><doi>10.1111/j.1346-8138.2011.01394.x</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | ALK Benign Case reports CD68 Child, Preschool Children Cytokines Eruptions Granulocyte-macrophage colony-stimulating factor histiocytosis Humans Magnetic resonance imaging Male Neuroimaging Nodules Remission, Spontaneous Touton giant cell Tumor necrosis factor- alpha Ultrasonography xanthogranuloma Xanthogranuloma, Juvenile - diagnosis Xanthogranuloma, Juvenile - etiology Xanthogranuloma, Juvenile - pathology |
| title | Juvenile xanthogranuloma with lichenoid appearance |
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