Stereocontrolled semi-syntheses of deguelin and tephrosin

We describe stereocontrolled semi-syntheses of deguelin and tephrosin, anti-cancer rotenoids isolated from Tephrosia vogelii. Firstly, we present a new two-step transformation of rotenone into rot-2'-enonic acid via a zinc-mediated ring opening of rotenone hydrobromide. Secondly, following conv...

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Veröffentlicht in:	Organic & biomolecular chemistry 2017-02, Vol.15 (7), p.1593-1596
Hauptverfasser:	Russell, David A, Freudenreich, Julien J, Ciardiello, Joe J, Sore, Hannah F, Spring, David R
Format:	Artikel
Sprache:	eng
Schlagworte:	Molecular Conformation Rotenone - analogs & derivatives Rotenone - chemical synthesis Rotenone - chemistry Stereoisomerism
Online-Zugang:	Volltext
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