Misexpression of Dickkopf-1 in endothelial cells, but not in chondrocytes or hypertrophic chondrocytes, causes defects in endochondral ossification

Developing cartilage serves as a template for long‐bone development during endochondral ossification. Although the coupling of cartilage and bone development with angiogenesis is an important regulatory step for endochondral ossification, the molecular mechanisms are poorly understood. One possible...

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Veröffentlicht in:	Journal of bone and mineral research 2012-06, Vol.27 (6), p.1335-1344
Hauptverfasser:	Oh, Hwanhee, Ryu, Je-Hwang, Jeon, Jimin, Yang, Siyoung, Chun, Churl-Hong, Park, Hongryeol, Kim, Hyung Joon, Kim, Woo-Shin, Kim, Hong-Hee, Kwon, Young-Guen, Chun, Jang-Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Antagonists Apoptosis Biological and medical sciences Body Size Body Weight Bone (endochondral) Bone and Bones - metabolism Bone and Bones - pathology Bone and Bones - physiopathology Bone Resorption - metabolism Bone Resorption - pathology Bone Resorption - physiopathology CARTILAGE Cartilage - metabolism Cartilage - pathology Chondrocytes Chondrocytes - metabolism Chondrocytes - pathology Chondrogenesis DICKKOPF (DKK)-1 Dkk1 protein ENDOCHONDRAL OSSIFICATION ENDOTHELIAL CELLS Endothelial Cells - metabolism Endothelial Cells - pathology Fundamental and applied biological sciences. Psychology Hypertrophy Intercellular Signaling Peptides and Proteins - metabolism Mice Mice, Transgenic Molecular modelling Neovascularization, Physiologic Organ Specificity Ossification Osteogenesis RANK Ligand - metabolism Receptor Protein-Tyrosine Kinases - metabolism Receptor, TIE-2 Skeleton and joints TRANSGENIC MICE Vertebrates: osteoarticular system, musculoskeletal system Wnt protein
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