Effect of the allelic variants of ABCB1, CYP2D6 and HTR3B on response of ramosetron to prevent chemotherapy‐induced nausea and vomiting in Korean cancer patients

Aim Despite appropriate use of antiemetics including 5‐hydroxytryptamine type 3 (5‐HT3) receptor antagonists, chemotherapy‐induced nausea and vomiting (CINV) is still an unsolved problem in patients with anticancer drugs. We examined whether the variants of ABCB1, CYP2D6 and HTR3B affect efficacy of...

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Veröffentlicht in:	Asia-Pacific journal of clinical oncology 2017-02, Vol.13 (1), p.53-60
Hauptverfasser:	Kang, Gaeun, Kim, Ka‐Rham, Shim, Hyun‐Jeong, Hwang, Jun‐Eul, Bae, Woo‐Kyun, Chung, Ik‐Joo, Kim, Hee‐Nam, Lee, Jongtae, Choi, Kyungmee, Shin, Hee‐Young, Kim, Jong‐Keun, Jeong, Seong‐Wook, Cho, Sang‐Hee
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antiemetics Antiemetics - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Antineoplastic drugs Antitumor agents Asian Continental Ancestry Group - genetics ATP Binding Cassette Transporter, Sub-Family B - genetics Benzimidazoles - administration & dosage Cancer Chemotherapy Clinical trials CYP2D6 protein Cytochrome P-450 CYP2D6 - genetics Cytochrome P450 Deoxyribonucleic acid DNA Dose-Response Relationship, Drug Drug Resistance - genetics Female Gene deletion Humans Male Middle Aged Nausea Nausea - chemically induced Nausea - genetics Nausea - prevention & control Neoplasms - drug therapy polymorphism ramosetron Receptors, Serotonin, 5-HT3 - genetics Serotonin Serotonin S3 receptors Statistical analysis Vomiting Vomiting - chemically induced Vomiting - genetics Vomiting - prevention & control
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