β‐cell specific T‐lymphocyte response has a distinct inflammatory phenotype in children with Type 1 diabetes compared with adults

Aim To examine the hypothesis that the quality, magnitude and breadth of helper T‐lymphocyte responses to β cells differ in Type 1 diabetes according to diagnosis in childhood or adulthood. Methods We studied helper T‐lymphocyte reactivity against β‐cell autoantigens by measuring production of the p...

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Veröffentlicht in:	Diabetic medicine 2017-03, Vol.34 (3), p.419-425
Hauptverfasser:	Arif, S., Gibson, V. B., Nguyen, V., Bingley, P. J., Todd, J. A., Guy, C., Dunger, D. B., Dayan, C. M., Powrie, J., Lorenc, A., Peakman, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aging Autoantibodies - analysis Autoantigens - metabolism Autoimmunity CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Child Child, Preschool Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - metabolism Female Humans Insulin-Secreting Cells - immunology Insulin-Secreting Cells - metabolism Interferon-gamma Release Tests Interleukin-10 - metabolism Male Models, Immunological Siblings Young Adult
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