PPARγ Modulation of Cytokine‐Stimulated MUC16 (CA125) Expression in Breast and Ovarian Cancer‐Derived Cells

ABSTRACT CA125 is serum tumor marker consisting of an epitope carried by a portion of the extremely large (>3 MDa), heavily glycosylated cell surface transmembrane mucin, MUC16. In malignancies, membrane bound mucins lose their polarized distribution, become aberrantly over‐expressed and protect...

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Veröffentlicht in:	Journal of cellular biochemistry 2017-01, Vol.118 (1), p.163-171
Hauptverfasser:	Morgado, Micaela, Carson, Daniel D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anilides - pharmacology Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism CA-125 Antigen - biosynthesis CA-125 Antigen - genetics CANCER Female Gene Expression Regulation, Neoplastic Humans Interferon-gamma - pharmacology MCF-7 Cells Membrane Proteins - biosynthesis Membrane Proteins - genetics MUC16 Neoplasm Proteins - agonists Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism PPAR gamma - agonists PPAR gamma - antagonists & inhibitors PPAR gamma - genetics PPAR gamma - metabolism PPARγ ROSIGLITAZONE Thiazolidinediones - pharmacology Tumor Necrosis Factor-alpha - pharmacology
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